急性早幼粒细胞白血病合并颅咽管瘤

本研究分析急性早幼粒细胞白血病（acutepromyelocyticleukernia，APL）合并颅咽管瘤的临床表现及治疗方案，提高对APL合并或继发第二肿瘤的认识。应用骨髓细胞形态学检查对APL进行确诊；应用免疫分型技术对骨髓中白血病细胞进行分析；应用分子生物学检测PML—RARa融合基因以定性及确定治疗前后定量变化；应用常规染色体核型技术及HSH技术以分析该患者细胞遗传特点。结果表明，急性早幼粒细胞白血病合并或继发第二肿瘤的临床表现多样，病情复杂。通过早期发现、及时治疗、多学科合作取得了良好的疗效，避免了误诊、漏诊延误诊治。结论：当急性早幼粒细胞白血病经过治疗缓解后，再出现其它临床症状时需考虑其他肿瘤的可能，临床上需仔细观察临床表现，早期诊断，及时治疗，以提高患者的生存率。

A Rare Case of Acute Promyelocytic Leukemia Accompanied by Benign Craniopharyngioma

The purpose of study was to analysis the clinical manifestation and treatment protocol of acute promyelocytic leukemia （APL） accompafied by craniopharyngioma so as to promote the understanding of this disease. The APL was diagnosed by morphologic examination of bone marrow cells, the leakemia bone marrow cells were analyzed by immunophenotyping technigue, the qualitative and quantitative changes of PML-PARa fusion gene before and after treatment were monitored by using molecular biological test; the cytogenetic features were analyzed by using conventional karyotype and FISH analysis. The results indicated that the clinical manifestation of this disease was diverse and disease status was complex. The good therapeutic efficacy could be achieved, the misdiagnosis and delayed treatment could be avoided through early detection, timely treatment and multidisciplinary cooperation. It is concluded that when other clinical symptoms reappear after APL achieves remission, the possibility of second tunor must be considered, the clirfical presentation should be carefully monitored, the early detection and timely treatment should be performed to improve the survival of patients.