富含血小板血浆与玻璃酸钠治疗早期踝关节骨性关节炎疗效对比

目的:对比富含血小板血浆(PRP)与玻璃酸钠在早期踝关节骨性关节炎中的应用效果,为临床提供参考。方法:60例早期踝关节骨性关节炎患者随机分成两组,各30例。A组给予玻璃酸钠注射剂关节腔注射,B组给予自体PRP关节腔注射。对比两组患者治疗1个月、2个月、3个月、6个月后疼痛视觉模拟评分(VAS)、踝关节Baird-Jackson评分、10m步行时间等指标变化,以及两组药品不良反应发生情况。结果:治疗1个月后开始,两组各项指标均较治疗前明显改善(P<0.05)。治疗1个月后,A组踝关节Baird-Jackson评分、VAS评分、10 m步行步数优于B组(P<0.05)。治疗3个月后,B组踝关节Baird-Jackson评分、VAS评分、10 m步行步数优于A组(P<0.05)。两组药品不良反应发生率无显著差异(P>0.05)。结论:关节腔内注射玻璃酸钠和PRP治疗早期踝关节骨性关节炎均有较好疗效,注射PRP在3~6个月时疗效优于注射玻璃酸钠。

Comparative Study of Platelet-rich Plasma and Sodium Hyaluronate in the Treatment of Early Ankle Osteoarthritis

Objective:To compare the effect of platelet-rich plasma(PRP)and sodium hyaluronate on early ankle osteoarthritis,provide reference for clinical practice.Methods:60 patients with early ankle osteoarthritis were randomly divided into two groups,each 30 cases.Group A was injected with sodium hyaluronate and group B was injected with platelet-rich plasma.Those with joint effusion try to withdraw the effusion and then inject medicine.Visual analogue(VAS)pain score,ankle Baird-Jackson score and 10 m walking time were compared between the two groups after 1 month,2 months,3 months and 6 months of treatment.Results:One month after treatment,all the indexes of the two groupswere significantly improved(P<0.05).One month after treatment,the Baird-Jackson score,VAS score and 10 m walking time in group A were better than those in group B(P<0.05).After 3 months of treatment,the Baird-Jackson score,VAS score and 10 m walking time in group B were better than those in group A(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion:Calcium hyaluronate and PRP can improve the therapeutic effect of early ankle osteoarthritis patients.The therapeutic effect of 3-6 months of PRP injection is better than that of sodium hyaluronate injection.