|
|||||
|
|
Analysis of Micelle Formation of an Adriamycin-Conjugated Poly(Ethylene Glycol)–Poly(Aspartic Acid) Block Copolymer by Gel Permeation Chromatography |
|
| Authors: | Yokoyama Masayuki Sugiyama Takumichi Okano Teruo Sakurai Yasuhisa Naito Mayumi Kataoka Kazunori |
| Affiliation: | (1) Institute of Biomedical Engineering, Tokyo Women's Medical College, Kawada-cho, Shinjuku-ku, Tokyo, 162, Japan;(2) Department of Materials Sciences and Technology & Research Institute for Biosciences, Science University of Tokyo, Yamazaki 2641, Noda-shi, Chiba, 278, Japan |
| Abstract: | The micelle-forming behavior of a drug–block copolymer conjugate adriamycm-conjugated poly(ethylene glycol)–poly(aspartic acid) block copolymer; PEG-P[Asp(ADR)] was analyzed by gel permeation chromatography (GPC). Four compositions of the conjugates were observed to form micellar structures in aqueous media, and their micelle-forming behavior was found to be dependent on the composition and media. These micelles did not reach equilibrium within short time periods like low molecular weight surfactants. One composition formed stable micelles in the presence of serum. |
| Keywords: | polymeric micelle drug delivery system drug targeting adriamycin block copolymer poly(ethylene glycol) |
| 本文献已被 SpringerLink 等数据库收录！ | |