| 环氧合酶-2及其抑制剂与肿瘤多药耐药 |
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| 引用本文： | 张玲,陈同钰.环氧合酶-2及其抑制剂与肿瘤多药耐药[J].国际药学研究杂志,2007,34(3):177-180. |
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| 作者姓名： | 张玲 陈同钰 |
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| 作者单位： | 苏州大学附属第三医院病理科,江苏,常州,213003 |
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| 摘 要： | 肿瘤多药耐药是目前化疗失败的最常见且最难解决的问题，环氧合酶-2参与肿瘤的发生发展，近年来一些研究表明,环氧合酶-2与肿瘤多药耐药密切相关，并且通过多条途径参与肿瘤多药耐药的发生，该文对环氧合酶-2及其抑制剂与肿瘤多药耐药的关系做一综述。
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| 关 键 词： | 环氧合酶-2 P糖蛋白 肿瘤多药耐药 |
| 文章编号： | 1001-0971(2007)03-0177-04 |
| 收稿时间： | 2006-11-8 |
| 修稿时间： | 2006年11月8日 |
Cyclooxygenase-2 and its inhibitor and multidrug resistance |
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| ZHANG Ling,CHEN Tong-yu.Cyclooxygenase-2 and its inhibitor and multidrug resistance[J].Foreign Medical Sciences(Section of Pharmarcy),2007,34(3):177-180. |
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| Authors: | ZHANG Ling CHEN Tong-yu |
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| Institution: | （The Third Affliated Hospital of Suzhou University, Changzhou 213003, China） |
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| Abstract: | At present, multidrug resistance(MDR) is the most common and difficult problem of failure of chemotherapy.Cyclooxygenase-2(COX-2) participated in the development of tumor. Recently, the study showed that COX-2 was closely related to multidrug resistance of tumers and played an important role in the development of MDR through many paths. In this article the relationship between COX-2 and MDR is reviewed. |
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| Keywords: | cyclooxygenase-2 P-glycoprotein multidrug resistance |
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