Ⅱ度烧伤病人皮肤角朊细胞ICAM—1的表达

目的 探讨Ⅱ度烧伤伤面愈合过程中角朊细胞间附分子－１（ＩＣＡＭ－１）的表达及其意义。方法 应用免疫组织化学染色技术，对烧伤后不同时间Ⅱ度烧伤皮肤组织角朊细胞ＩＣＡＭ－１的表达进行动态观察。８例健康人皮肤，６例烧伤病人正常皮肤及８例Ⅱ度烧伤愈合后增生性瘢痕组织为对照组。结果 健康人正常皮肤基底层细胞ＩＣＡＭ－１可低表达，烧伤病人正常皮肤基底层细胞ＩＣＡＭ－１可表达增强。Ⅱ度他面基底层细胞伤后１周内Ｉ

The expression of ICAM-1 on the keratinocytes in second degree human burn skin]

OBJECTIVE: To investigate the significance of changes in intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes(KCs) during wound healing of second degree burn. METHODS: With immunohistochemistry technique, the ICAM-1 expression in second degree burn wounds in patients were investigated at four different postburn periods. The normal skins from 6 burn patients (BNG), the normal skins from 8 healthy volunteers (HVG) and the scar tissues (SG) from 8 patients served as controls. RESULTS: There was poor expression of ICAM-1 on basal cells in normal skins of healthy volunteers, while the expression of ICAM-1 enhanced in normal skins of burn patients. On basal cells in second degree burn wounds, the expression of ICAM-1 slightly increased in the first week postburn, obviously enhanced in the second week, and in the third or fourth week, the expression continued to keep strong. In addition, the ICAM-1 in KCs showed polar distribution, and the expression of ICAM-1 markedly enhanced on the multilayer KCs in neogenetic epithelium and the positive cells arranged columnarly. CONCLUSION: The enhanced expression of ICAM-1 on KCs in second degree burn wounds might be related to invasion of inflammatory cells beneath wound. It might play a role in inducing proliferation and migration of KCs and accelerating epithelization.