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| Vascular endothelial growth factor expressing mesenchymal stem cells improves cardiac function in chronic myocardial infarction in pigs | |
| 引用本文： | Yi F,Guo WY,Lü AL,Wang HC,Li H,Li WJ,Liu B,Zhang DX,Luan RH,Cheng HX,Li F,Qin T,Zhao ZJ,Gao F,Jia GL. Vascular endothelial growth factor expressing mesenchymal stem cells improves cardiac function in chronic myocardial infarction in pigs[J]. 中华医学杂志(英文版), 2006, 119(19): 1664-1668 |
| 作者姓名： | Yi F Guo WY Lü AL Wang HC Li H Li WJ Liu B Zhang DX Luan RH Cheng HX Li F Qin T Zhao ZJ Gao F Jia GL |
| 作者单位： | [1]Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi＇an 710032, China [2]Department of Physiology, Fourth Military Medical University, Xi＇ an 710032, China |
| 基金项目： | This work was supported in part by grants from the National Nature Science Foundation of China （No. 30471923 and No. 30570667） and Shaanxi Provincial Science Grant （No. 2004C2-03）. We appreciate the excellent technical assistance of LI Li, LI Wei and ZHANG Rong-qing. |
| 摘 要： | Transplantation of mesenchymal stem cells （MSCs） for myocardial reconstruction has shown promise in both animal models and human phase 1 clinical studies. Vascular endothelial growth factor （VEGF） is a strong therapeutic agent for treating ischaemia by inducing angiogenesis. The feasibility of ex vivo MSCs mediated gene transfer is documented. Matsumoto and colleagues have recently reported genetically engineered MSCs carrying VEGF165 delivery for revascularization in a model of acute myocardial infarction （MI）. The promising data from our laboratory in both angiogenesis and MSCs transplantation in cunicular heart model of acute MI have prompted us to attempt the combined and simultaneous application of the two strategies. |
| 关 键 词： | 血管内皮生长因子 干细胞 心肌梗死 治疗 |
| 收稿时间： | 2006-03-01 |
Vascular endothelial growth factor expressing mesenchymal stem cells improves cardiac function in chronic myocardial infarction in pigs |
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| Yi Fu,Guo Wen-yi,Lü An-lin,Wang Hai-chang,Li Hu,Li Wei-jie,Liu Bing,Zhang Dian-xin,Luan Rong-hua,Cheng He-xiang,Li Fei,Qin Tao,Zhao Zhi-jing,Gao Feng,Jia Guo-liang. Vascular endothelial growth factor expressing mesenchymal stem cells improves cardiac function in chronic myocardial infarction in pigs[J]. Chinese medical journal, 2006, 119(19): 1664-1668 | |
| Authors: | Yi Fu Guo Wen-yi Lü An-lin Wang Hai-chang Li Hu Li Wei-jie Liu Bing Zhang Dian-xin Luan Rong-hua Cheng He-xiang Li Fei Qin Tao Zhao Zhi-jing Gao Feng Jia Guo-liang |
| Affiliation: | 1. Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China 2. Department of Physiology, Fourth Military Medical University, Xi'an 710032, China |
| Abstract: | |
| Keywords: | myocardial infarction mesenchymal stem cell transplantation vascular endothelial growth factor ventricular function |
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