垂体腺瘤100例临床病理分析

目的：探讨垂体腺瘤的临床病理特征。方法：收集1999年10月-2002年12月于本科病理确诊为垂体腺瘤患100例，回顾性分析其苏木精—伊红(HE)染色、网状纤维特殊染色(Comeri法)、PAS特殊染色及免疫组织化学染色临床病理资料。结果：根据免疫组织化学检测结果，100例垂体腺瘤中，45％为单激素腺瘤，包括17例催乳素细胞腺瘤(prolactin cell adenoma，PRL型腺瘤)、11例生长激素细胞腺瘤(growth hormone cell adenoma,GH型腺瘤)、9例促肾上腺皮质激素细胞腺瘤(adrenocorticotropic hormone cell adenoma,ACTH型腺瘤)、8例卵泡刺激素—黄体生成素细胞腺瘤(follicle-stimulating hormone/Iuteinizing hormone cell adenoma,FSH／LH型腺瘤)，13％为双激素腺瘤，31％为多激素腺瘤及11％为无功能性腺瘤。按临床有无激素分泌的症状，分为功能性腺瘤(89％)和无功能性腺瘤(11％)。结论：虽然垂体腺瘤的组织学形态呈多样性，但由于免疫组织化学检测结果与患的临床表现密切相关，因此可根据免疫组织化学检测结果对其进行功能性分类、研究，并指导临床治疗。

Clinicopathological Analysis of 100 Cases of Pituitary Adenoma

Objective:To an al yze data of clinicopathological characteristics in100cases of pituitary adenoma. Methods:Retro-spective analysis were performed by hematoxylin-eosin stain,ret icular fiber-specific stain(Gomeri),PAS-specific stain and immunohistochemical stain in100cases of pituitary adenoma from Oct1999through Dec2002.Results:One hundred cases of pituitary adenoma were classified by immunohistochemistry,of th em,45%were monohormonal adenoma,inclu-ding17cases of prolactin cell adenoma,11c ases of growth hormone cell adenoma,9cases of adrenocorticotropic hormone cell a denomas and8cases of follicle-stimulating hormonal/luteinizing hormone cell ade noma.Thirteen percent were dou-ble hormonal adenoma,31%were multiple hormones-secreting adenoma and the remaining11%were hormone negative adenoma.These patien ts were clinically classified into functional pituitary adenoma(89%)and non-fun ctional adenoma(11%)according to the clinical symptoms caused by secreted hormon e.Conclusions:Despite of the variform histo-mor-phological characteristics of pituitary adenoma,the close correlation of immunohistochemical results with clin ical manifes-tations suggests that it might be useful in classification and tre atment of pituitary adenoma.