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| 急性淋巴细胞白血病复发与p16蛋白表达缺失之间关系的临床研究 | |
| 引用本文： | 郑喆. 急性淋巴细胞白血病复发与p16蛋白表达缺失之间关系的临床研究[J]. 中国医药指南, 2011, 9(16): 21-22 |
| 作者姓名： | 郑喆 |
| 作者单位： | 辽宁省沈阳市第四人民医院血液内科,辽宁沈阳,110031 |
| 摘 要： | 目的探讨急性淋巴细胞白血病的复发与患者体内p16蛋白表达缺失值之间的关系及其临床意义。方法收集2004年4月至2010年8月在沈阳市第四人民医院血液科门诊就诊、住院的急性淋巴细胞白血病(ALL)患者40例;同期单纯性贫血患者40例(作为对照组)的临床资料,分别采集他们的少许骨髓样本,分离骨髓液中的淋巴细胞,应用APAAP法、免疫组化检测方法,来检测受检淋巴细胞内的棕色颗粒的多少,以确定其p16蛋白表达是否缺失。结果对照组和ALL不同病期患者p16蛋白表达(缺失)值不同,确诊为单纯贫血的患者p16蛋白表达值,均为阳性表达;急性淋巴细胞白血病(ALL)不同病期患者组的p16蛋白表达值,均为阴性表达;动态检测15例ALL患者的p16蛋白缺失值,发现ALL复发期的人体骨髓p16蛋白表达缺失值显著低于ALL完全缓解期的该值。结论 p16蛋白表达缺失在ALL复发机制中起着重要作用,动态检测完全缓解后患者的p16蛋白表达缺失值,能对预测、确诊其ALL是否出现早期复发提供依据。 |
| 关 键 词： | p16抑癌基因失活 p16蛋白表达缺失 急性淋巴细胞白血病复发 早期诊断 |
Clinical Research to the Relationship Between the Recurrence of the Acute Lymphoblastic Leukemia and the p16 Protein Missing |
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| ZHENG Zhe. Clinical Research to the Relationship Between the Recurrence of the Acute Lymphoblastic Leukemia and the p16 Protein Missing[J]. Guide of China Medicine, 2011, 9(16): 21-22 | |
| Authors: | ZHENG Zhe |
| Affiliation: | ZHENG Zhe(Internal Medicine of Hematology,The Fourth People's Hospital of Shenyang,Shenyang 110031,China) |
| Abstract: | Objective Discuss the relationship between the recurrence of the acute lymphoblastic leukemia and the P16 protein missing values in the vivo of patients,reveal the clinical significance.Method Collect clinical data of 40 patients of acute lymphoblastic leukemia who were in hospital during April 2004 and August 2010 and 40 sufferers of simple anemia(as the control group),pick the bone marrow samples of them,and separate the lymphocytes in their bone marrow fluid.In order to make sure whether P16 protein is m... |
| Keywords: | p16 inactivation of tumor suppressor genes P16 protein loss of expression Recurrence of ALL Early diagnosis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |