神经节苷脂在脑梗死治疗中的药物经济学评价

目的:探讨脑梗死患者入院治疗中应用神经节苷脂注射液的临床疗效及药物经济学效果。方法:利用医院信息管理系统,从南京军区南京总医院2009年9月—2010年8月期间住院的脑梗死患者中,筛选出治疗有效的病例115例,根据方案分为2组:使用神经节苷脂注射液组(Ⅰ组)和未使用神经节苷脂注射液组(Ⅱ组)。Ⅰ组的患者在常规治疗的基础上给予神经节苷脂40～100 mg,静脉滴注,1日1次,治疗时间2～3周。2组结果用药物经济学成本-效果分析方法进行比较。结果:2组的成本分别为42 061.19元、26 972.42元。Ⅰ组与Ⅱ组的治疗结果(有效率)分别为89.66%、73.68%,成本效果比分别为469.11元/单位效果、366.08元/单位效果。在Ⅱ组的基础上,Ⅰ组每增加1个单位效果多花费的成本为146.45元。结论:Ⅱ组的成本-效果比较低,Ⅰ组有效率较高。如果患者经济条件允许,则在治疗方案中加用神经节苷脂注射液有利于提高疗效。

Pharmacoeconomic Evaluation of Gangliosides in Treating Cerebral Infarction

OBJECTIVE：To evaluate the clinical efficacy and pharmacoeconomic efficacy of ganglioside injection for cerebral infarction.METHODS：By using hospital information management system,a total of 115 successfully treated cerebral infarction cases hospitalized in Nanjing General Hospital of Nanjing Military Command from Sept.2009 to Aug.2010 were assigned to receive either add-on ganglioside injection once daily at a dose of 40-100 mg by i.v.drip for 2-3 weeks（Group Ⅰ）or routine therapy alone（Group Ⅱ）.Cost-effectiveness analysis in pharmacoeconomics was performed on the two groups.RESULTS：The costs,effective rates,and cost-effectiveness ratios of Group Ⅰ vs.Group Ⅱ were 42 061.19 vs.26 972.42 Yuan,89.66% vs.73.68%,and 469.11 Yuan/unit vs.366.08 Yuan/unit,respectively.The increment cost for increase of each unit of effectiveness in Group Ⅰ was 146.45 Yuan more than in the Group Ⅱ.CONCLUSION：The cost-effectiveness ratio in Group Ⅱ was lower than in Group Ⅰ but the effectiveness rate in Group Ⅰ was higher.If economically possible,the addition of ganglioside injection can result in improved efficacy for cerebral infarction.