| PTTG基因在人乳腺癌中的原位表达及其意义 |
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| 引用本文： | 王成海,贾筱琴,李国利,冯振卿. PTTG基因在人乳腺癌中的原位表达及其意义[J]. 实用临床医药杂志, 2003, 7(2): 142-144 |
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| 作者姓名： | 王成海 贾筱琴 李国利 冯振卿 |
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| 作者单位： | 南京医科大学病理学系,江苏,南京,210049;扬州大学医学院病理学教研室,江苏,扬州,2254001 |
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| 摘 要： | 目的 研究PTTG基因在乳腺癌表达的临床病理意义。方法 应用原位杂交 (DNA RNA)技术检测 66例人乳腺癌、2 7例乳腺小叶增生及 5 4乳腺正常组织中PTTGmRNA。结果 PTTGmRNA在乳腺癌、乳腺小叶增生和乳腺正常组织阳性率分别为 71 2 % (4 7/66)、5 1 9% (14 /2 7)和 11 1% (6/5 4) ,乳腺癌和乳腺正常组织之间有显著差异 (P <0 0 5 ) ,乳腺小叶增生和乳腺正常组织之间也有显著差异 (P <0 0 5 ) ;PTTGmRNA的表达与淋巴结转移无统计学意义 (P >0 0 5 )。结论 PTTG基因的过度表达可能参与了人乳腺癌的发生发展过程
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| 关 键 词： | 乳腺癌 癌基因 PTTG 原位杂交 |
| 文章编号： | 1672-2353(2003)02-0142-03 |
| 修稿时间： | 2003-03-06 |
Expression of pituitary tumor transforming gene in human breast carcuonoma |
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| WANG Cheng?hai ,JIA Xiao?qin ,LI Guo?li ,et al. Expression of pituitary tumor transforming gene in human breast carcuonoma[J]. Journal of Clinical Medicine in Practice, 2003, 7(2): 142-144 |
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| Authors: | WANG Cheng?hai JIA Xiao?qin LI Guo?li et al |
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| Affiliation: | WANG Cheng?hai 1,JIA Xiao?qin 2,LI Guo?li 2,et al |
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| Abstract: | Objective: To investigate the relationship between expression of PTTG gene and oncogenesis in human breast carcinomas (BRCA). Methods: Situ hybridization(DNA?RNA) was used to detect the expression of PTTG gene in 66 cases of BRCA. Results: The positive rates of PTTG mRNA were 71 2%(47/66) in BRCA, 51 9%(14/27) in breast lobule hyperplasia tissue and 11 1%(6/54) in breast nomal tissue. The expression rate of BRCA and breast lobule hyperplasia tissue was significant higher than that of breat normal tissue(P<0 05). No significant correlation was found between the expression of PTTG gene and the metastasis of lymph node(P>0 05). Conclusion: Over?expression of oncogene PTTG may be related to human breast carcinogenesis. |
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| Keywords: | breast cancer oncogene PTTG situ hybridization |
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