丙泊酚抑制双腔支气管插管心血管反应的有效浓度

目的:评价丙泊酚抑制双腔支气管插管心血管反应的有效浓度（effective concentration, EC）。方法:纳入拟行全身麻醉单侧肺部手术的患者100例，按年龄分为青年组和中年组。青年组患者给予丙泊酚靶控输注（target controlled infusion, TCI）血浆浓度3.0 mg/L，中年组患者...

Effective concentration of propofol for inhibiting cardiovascular response during double-lumen endobronchial intubation

Objective To determine the effective concentration(EC)of propofol for inhibiting cardiovascular response during double-lumen endobronchial intubation.Methods A total of 100 patients who were scheduled for single-lung surgery under general anesthesia were enrolled and divided into two groups according to their ages:a young group and a middle-aged group.Patients in the young and middle-aged group were given propofol through target controlled infusion(TCI)and achieved a plasma concentration of 3.5 mg/L and 2.5 mg/L,respectively.During double-lumen endobronchial intubation,the previous case determined the concentration of propofol in the next case.Then,the effective concentration of propofol was calculated on the basis of final observation.Results During double-lumen endobronchial intubation,the median effective concentration(EC50)of propofol for inhibiting cardiovascular response was 3.594 mg/L95%confidence interval(CI)1.992-3.594]for the young group and 2.938 mg/L(95%CI 2.426-3.104)for the middle-aged group.Meanwhile,the 95%effective concentration(EC95)of propofol was 4.031 mg/L(95%CI 3.810-4.917)for the young group and 3.479 mg/L(95%CI 3.284-4.283)for the middle-aged group.Conclusions During double-lumen endobronchial intubation,the plasma target controlled concentration EC95 of propofol for inhibiting cardiovascular response was 4.031 mg/L for the young group and 3.479 mg/L for the middle-aged group.