桉叶油抗金黄地鼠皮脂腺斑增生的研究

目的 观察桉叶油对金黄地鼠皮脂腺斑的影响,探讨外用桉叶油乳膏治疗痤疮的机制.方法 将24只雄性金黄地鼠随机分为空白组、基质组、桉叶油乳膏组、阳性对照组,每组6只,分别于双侧皮脂腺斑处涂抹蒸馏水、基质、桉叶油乳膏、0.025％维A酸乳膏,连续给药4周后,观察各组金黄地鼠皮脂腺斑面积变化及组织病理学改变.结果 给药后,与空...

Study on Effect of Eucalyptus Oil on Proliferation of Sebaceous Gland Spots in Golden Hamsters

Objective To observe the effect of eucalyptus oil on sebaceous gland spots in golden hamsters,and explore the mechanism of external use of eucalyptus oil cream in the treatment of acne.Methods 24 male golden hamsters were randomly divided into blank group,matrix group,eucalyptus oil cream group and positive control group,with 6 rats in each group.Distilled water,matrix,eucalyptus oil cream and 0.025%vitamin A cream were applied to bilateral sebaceous gland spots.After continuous treatment for 4 weeks,the change of sebaceous gland spots area of golden hamster in each group and histopathological changes were observed.Results After administration,compared with blank group and matrix group,the ipsilateral sebaceous plaque area of golden hamsters in each treatment group decreased,and the difference was statistically significant(P<0.05).At the same time,the thickness of sebaceous gland spots decreased,the gland atrophic,the number of glandular leaves decreased,and the arrangement was loose.Compared with the positive control group,the area of sebaceous spots on the right side of the eucalyptus oil cream group was reduced,and the difference was statistically significant(P<0.05).Meanwhile,the sebaceous gland spots were small and loosely arranged.Conclusion Eucalyptus oil can effectively inhibit sebaceous gland spots hyperplasia,which may be one of the mechanisms of acne treatment.