| CRISPR/Cas系统在感染性疾病诊断中的应用 |
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| 引用本文： | 赵爽,陈鸣.CRISPR/Cas系统在感染性疾病诊断中的应用[J].中华检验医学杂志,2021(2). |
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| 作者姓名： | 赵爽 陈鸣 |
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| 作者单位： | 陆军军医大学西南医院检验科 |
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| 基金项目： | 国家自然科学基金(81430053,81972027,82030066)。 |
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| 摘 要： | 成簇规律间隔短回文重复序列(CRISPR)/CRISPR相关蛋白(Cas)系统,作为原核生物的适应性免疫防御系统,近年来已经被开发成为一种高效的分子诊断工具,其特异、灵敏、快速、便捷等优势使得其在分子诊断领域,尤其是在感染性疾病的诊断上有着极佳的发展前景。本文旨在对CRISPR/Cas系统在感染性疾病诊断的应用现状、优势和局限以及未来的研究方向做一介绍和探讨。
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| 关 键 词： | 分子诊断技术 感染性疾病 核酸检测 CRISPR/Cas COVID-19 |
Application of CRISPR/Cas systems in the diagnosis of infectious diseases |
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| Zhao Shuang,Chen Ming.Application of CRISPR/Cas systems in the diagnosis of infectious diseases[J].Chinese Journal of Laboratory Medicine,2021(2). |
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| Authors: | Zhao Shuang Chen Ming |
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| Institution: | (Department of Clinical Laboratory Medicine,Southwest Hospital,Army Medical University,Chongqing 400038,China) |
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| Abstract: | The clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated proteins(Cas)systems,as an adaptive immune defense system for prokaryotes,has developed into an efficient molecular diagnostic tool in recent years.It has the advantages of great specificity,high sensitivity,time-saving,and easy operation.Thus,this system has broad prospects in molecular diagnosis,especially the diagnosis of infectious diseases.In this article,the current status of the application of the CRISPR/Cas system in the diagnosis of infectious diseases,its advantages and limitations were introduced,as well as future trends. |
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| Keywords: | Molecular Diagnostic Techniques Infectious disease Nucleic acid testing CRISPR/Cas COVID-19 |
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