含聚乙二醇环孢素注射液致过敏性休克1例分析

目的 分析含聚乙二醇环孢素注射液致1例过敏性休克的原因,提示临床重视分析药物致敏成分.方法 对1例重型再生障碍性贫血患者行造血干细胞移植过程中输注环孢素注射液过敏性休克原因进行诺氏评分与文献分析.结果 诺氏评分量表评估为11分,考虑过敏反应"肯定"与环孢素注射液输注有关.结论 含聚乙二醇成分的药物出现过敏反应一定要细致...

One Case of Anaphylaxis Induced by Peg-containing Cyclosporine Injection

Objective To analyze one case of anaphylactic shock caused by cyclosporine injection containing polyethylene glycol(PEG)so as to highlight the need to analyze the potential sensitizing components of the drug.Methods The causes of anaphylactic shock induced by cyclosporine injection during hematopoietic stem cell transplantation in a patient with severe aplastic anemia were analyzed according to the Knoop's score and literature analysis.Results The score was 11,and the"positive"allergic reaction was related to the infusion of cyclosporine injection.Conclusion In case of allergic reaction of drugs containing polyethylene glycol,the causes of allergic reactions need to be analyzed and evaluated with proper evaluation tools.Once the allergic reactions are proved to be related to polyethylene glycol,clinicians should be alert to the possible fatal adverse reactions caused by other drugs containing polyethylene glycol components when they are reused.The adverse reactions should be identified and treated immediately,or other drugs without these ingredients should be used.