促排汤序贯治疗对多囊卵巢综合征患者行控制性超促排卵的影响

目的 探讨促排汤序贯治疗对多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者行控制性超促排卵(controlled ovarian hyperstimulation,COH)的影响.方法 将60例行COH的PCOS患者随机分为观察组和对照组,每组30例.其中,观察组中超重患者19人,体质...

The Effect of Sequential Method of Cupai Decoction on Patients with Polycystic Ovary Syndrome During Controlled Ovarian Hyperstimulation

Objective To investigate the effect of sequential method of Cupai Decoction on patients with polycystic ovary syndrome(PCOS)during controlled ovarian hyperstimulation(COH).Methods 60 patients with PCOS who underwent COH were randomly divided into the treatment group and the control group,30 cases in each group.In the treatment group,19 patients were overweight and 11 patients had normal body mass index(BMI).In the control group,there were 20 overweight patients and 10 normal BMI patients.The COH(antagonist regimens)protocol was used in both groups,the treatment group was given sequential method of Cupai Decoction intervention on the basis of the control group,both groups treated in one COH period.The amount and duration of gonadotropins(Gn),the number of retrieved eggs,the number of fertilization,fertilization rate,the number of high-quality embryo,high-quality embryo rate,ovarian hyperstimulation syndrome incidence were compared between the two groups.Results The quality embryo rate and fertilization rate of the observation group were higher than those of the control group(P<0.05);there were no significant differences in COH indexes among different BMI patients in the observation group(P>0.05),but the fertilization rate of overweight patients in the control group was significantly lower than that of normal BMI patients(P<0.05),and the rate of excellent embryo had a downward trend compared with that of normal BMI patients(P=0.05);in overweight patients,the fertilization rate and embryo excellent rate in observation group were higher than those in control group(P<0.05).Conclusion Sequential method of Cupai Decoction intervention can achieve higher quality embryos in patients with PCOS undergoing COH,which lays a foundation for further improving the outcome of in vitro fertilization and embryo transfer.