Obesity, Pancreatitis, and Pancreatic Cancer |
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Authors: | Andrew A Gumbs |
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Institution: | (1) Department of Surgery, Division of Upper GI and Endocrine Surgery, Columbia University College of Physicians and Surgeons, New York-Presbyterian Hospital, Herbert Irving Pavilion, 161 Fort Washington Ave, 8th Floor, New York, NY 10032, USA |
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Abstract: | The only universally accepted risk factors for the development of pancreatic cancer are a positive family history or a history
of smoking. Although the contribution of pancreatitis to pancreatic carcinogenesis has been debated for decades in the epidemiology
literature, the actual mechanism is still unclear. With the rising epidemic of obesity, scientists have begun to focus on
the contribution of chronic inflammatory state of morbidly obese patients in an effort to better understand the contribution
of inflammation to the comorbidities of obesity. Notably, population studies are beginning to show that one of the most serious
potential comorbidities of obesity is an increased lifetime risk of developing cancer. In this article, the current literature
that exists supporting this Chronic Inflammatory Hypothesis as it pertains to obesity and pancreatic carcinogenesis is reviewed.
To date, studies have focused on interleukin-6, a cytokine known to play a role in obesity, chronic pancreatitis and pancreatic
cancer. The anti-inflammatory adipocytokine, adiponectin, has also shown promise as a key player in this mechanism and has
recently been found to be more specific than standard tumor markers in differentiating pancreatic cancer from chronic pancreatitis.
If the pathogenesis of pancreatic cancer is related to hormone levels associated with obesity, such as adipocytokines, and
cytokines associated with chronic inflammation, this could potentially lead to the development of new pancreatic cancer tumor
markers and ultimately new therapies and methods of prevention.
The author has no conflicts of interest to disclose. |
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Keywords: | Pancreatic carcinogenesis Cytokines Adipocytokines Adiponectin Leptin |
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