| 复方丹参注射液对大鼠脊髓损伤后肢体运动功能的影响 |
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| 引用本文： | 刘德明,刘曾旭,王文敏,刘德伍,杨宝林. 复方丹参注射液对大鼠脊髓损伤后肢体运动功能的影响[J]. 中药药理与临床, 2002, 18(2): 6-8 |
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| 作者姓名： | 刘德明 刘曾旭 王文敏 刘德伍 杨宝林 |
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| 作者单位： | 1. 江西医学院解剖学教研室,南昌,330006
2. 江西医学院第一附属医院烧伤研究所 |
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| 基金项目： | 国家自然科学基金资助项目 (No30 0 60 0 34)，江西省自然科学基金资助项目 |
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| 摘 要： | 目的 :观察复方丹参注射液治疗脊髓损伤后肢体运动功能的变化 ,探讨丹参对大鼠脊髓损伤的保护和促进修复作用及其作用机理。方法 :大鼠按Allen改良法制备脊髓损伤动物模型 ,分别在术前和术后用复方丹参注射液腹腔注射。用斜板试验法和BBB(Bosso ,BeattieandBresnahan )评分法观察大鼠脊髓损伤后运动功能的变化。结果 :用药组大鼠脊髓损伤后肢体运动功能恢复较快 ,术前与术后用药组动物的运动功能恢复程度无显著性差异。结论 :丹参对大鼠实验性急性脊髓损伤后运动功能的恢复有促进作用。
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| 关 键 词： | 脊髓损伤 复方丹参注射液 运动功能 |
The effect of Salvia miltiorrhiza on the hindlimbs locomotor function after acute spinal cord injury in rats |
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| Liu Deming,Liu Zenxu,Wang Wenmin,et al.. The effect of Salvia miltiorrhiza on the hindlimbs locomotor function after acute spinal cord injury in rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2002, 18(2): 6-8 |
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| Authors: | Liu Deming Liu Zenxu Wang Wenmin et al. |
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| Abstract: | Objective: To study the protective effect on spinalcord injury and regeneration promoted with Salvia milteorrhiza (SM), the changes of hindlimbs locomotor after spinal cord injury treated with SM were observed. Method: Animal models of acute spinalcord injury were made in 46 Wistar rats by the method of Allens technique. The rats were divided into four groups: normal group without spinal cord injury, model control group, pre-operation treated with SM and post-operation treated with SM. The inclined plane test and BBB(Bosso,Beattie and Bresnahan) scores method were used to evaluate the changes of hindlimbs locomotor function in the rats. Result: the restoration of locomotor was distinct in the rats treated with SM. There were no significant difference in locomotor function between the rats treated pre-operation and post-operation. Conclusion: The SM can promote the locomotor function after spinal cord injury. |
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| Keywords: | Spinal cord injury Salvia milteorrhiza locomotor function |
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