| 电针对血管性痴呆大鼠海马突触蛋白Ⅰ表达的影响 |
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| 引用本文： | 王晅,朱燕珍.电针对血管性痴呆大鼠海马突触蛋白Ⅰ表达的影响[J].山东中医药大学学报,2012(6):524-526. |
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| 作者姓名： | 王晅 朱燕珍 |
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| 作者单位： | [1]福建中医药大学,福建福州350122 [2]福建中医药大学中西医结合学院,福建福州350122 |
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| 基金项目： | [基金项目]国家自然基金青年科学基金项目（编号：81001541）,福建省教育厅A类课题（编号：JA09140） |
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| 摘 要： | 目的:探讨电针治疗对血管性痴呆大鼠学习记忆能力的影响及其作用机制。方法:采用双侧颈总动脉结扎法制作血管性痴呆大鼠模型,以电针治疗,Morris水迷宫检测大鼠的学习记忆能力,western blot检测海马突触蛋白Ⅰ的表达。结果:电针治疗可明显改善血管性痴呆大鼠的学习记忆能力,增加海马突触蛋白Ⅰ表达(P<0.05)。结论:电针治疗通过改善血管性痴呆大鼠海马突触蛋白Ⅰ表达,从而改善大鼠的学习记忆能力。
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| 关 键 词： | 电针 血管性痴呆 大鼠 突触蛋白Ⅰ 海马 学习记忆能力 |
Effect of electro-acupuncture on expression of synapsin I in hippocampus of vascular dementia rats |
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| WANG Xuan,ZHU Yan-zhen.Effect of electro-acupuncture on expression of synapsin I in hippocampus of vascular dementia rats[J].Journal of Shandong University of Traditional Chinese Medicine,2012(6):524-526. |
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| Authors: | WANG Xuan ZHU Yan-zhen |
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| Institution: | 1 .Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China ; 2.College of Integration of Traditional and Western Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350122, China) |
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| Abstract: | Objective：To determine the effect of electro-acupuncture on the learning and memory ability of vascular dementia rats and explore its molecular mechanism. Methods：The models were established by Bilateral common carotid artery ligation and treated by electro-acupuncture. Morris water maze was used to assessed the learning and memory ability of rats. The expressions of synapsin I in hippocampus were measured by western blot. Results： Electro-acupuncture treatment improved the learning and memory ability of vascular dementia rats and increased the expressions of synapsin I in hippocampus（P〈0.05）. Conclusion：Electro-acupuncture promote the recognition ability of vascular dementia rats by improving the expression of synapsin I. |
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| Keywords: | electro-acupuncture vascular dementia rat synapsin I hippocampus learning and memory ability |
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