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| 咪唑斯汀等几种抗组胺药对小鼠接触性皮炎作用的实验研究 | |
| 引用本文： | 陈晶,何春涤,王雅坤,陈洪铎. 咪唑斯汀等几种抗组胺药对小鼠接触性皮炎作用的实验研究[J]. 临床皮肤科杂志, 2005, 34(3): 154-156 |
| 作者姓名： | 陈晶 何春涤 王雅坤 陈洪铎 |
| 作者单位： | 沈阳市第七人民医院皮肤科,辽宁,沈阳,110003;中国医科大学第一附属医院皮肤科,辽宁,沈阳,110001 |
| 摘 要： | 目的：观察几种抗组胺药对小鼠接触性皮炎的疗效及对表皮朗格汉斯细胞(LCS)数目的影响。方法：制作小鼠接触性皮炎模型，测量用药各组鼠左耳中部厚度变化及应用ABC免疫组化法测定LCS的数目。结果：对诱发皮炎前、后24h鼠耳厚度差的比较，咪唑斯汀组作用较强；各实验组与对照组比较，OX4 LCs、OX3*LCs均明显减少。结论：几种抗组胺药对小鼠迟发型超敏反应均有抑制作用，咪唑斯汀的作用较强；几种抗组胺药可使表皮LCs数目呈不同程度的减少；抗组胺药对迟发型超敏反应的抑制作用可能与LCs的数目减少有关，LCs数目的减少可能是其抑制迟发型超敏反应的机制之一。 |
| 关 键 词： | 抗组胺药 接触性皮炎 小鼠 |
| 文章编号： | 1000-4963(2005)03-0154-03 |
| 修稿时间： | 2004-05-08 |
Experimental study of the effects of some antihistamines on the contact dermatitis model of mice |
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| CHEN Jing,HE Chun-di,WANG Ya-kun,CHEN Hong-duo. Experimental study of the effects of some antihistamines on the contact dermatitis model of mice[J]. Journal of Clinical Dermatology, 2005, 34(3): 154-156 | |
| Authors: | CHEN Jing HE Chun-di WANG Ya-kun CHEN Hong-duo |
| Abstract: | Objective: To observe the effects of several antihistamines on the murine contact dermatitis and their influence on the number of Langerhans' cells (LCs) in vivo. Methods: The murine contact dermatitis was induced by a topical application of DNCB. The swelling was evaluated by measuring the thickness in the middle part of the left ear of mice before and after the irritation of DNCB. The number of LCs was also counted by an immunohistochemical staining. Results: Comparing with negative control, the swelling was significantly less in all antihistamine -treated groups. The effect of anti-swelling was most predominant in the group treated by mizolastine. Compared with the negative control group, the numbers of OX4+LCs,OX3+LCs in all antihistamine-treated groups were greatly reduced. Conclusions: These antihistamines can more or less reduce the swelling induced by DNCB. This effect may be concerned with the reduction of epidermal LCs< |
| Keywords: | antihistamines contact dermatitis mice |
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