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微创介入法观察家兔急性肺损伤模型的血流动力学变化
引用本文:唐立钧 高兴亚 等. 微创介入法观察家兔急性肺损伤模型的血流动力学变化[J]. 南京医科大学学报(自然科学版), 2001, 21(2): 129-131
作者姓名:唐立钧 高兴亚 等
作者单位:[1]南京医科大学第一附属医院放射科,江苏南京210029 [2]南京医科大学生理学教研,江苏南京210029
摘    要:
目的:建立油酸家兔急性损伤的模型,并用介入这种策创的方法来检测从外周静脉注入不同剂量油酸后家兔血流动力学的变化。方法:分别从对照组和油酸组家兔的外周静脉注入等量的生理盐水和油酸,分4次注射,剂量分别为0.06,0.04,0.04,0.04ml/kg,记录每次注射后5,10,15min时肺动脉压,主动脉压和心率的数值。结果:随着油酸剂量的增加,赆率变慢,主动脉压降低,肺动脉压先升高后降低。结论:油酸的剂量在0.06ml/kg或0.10ml/kg时,血流动力学的变化最为显著。

关 键 词:急性肺损伤 家兔 动物模型 血流动力学 微创介入法

The Hemodynamic Changes in the Rabbit Model of Acute Lung Injury Investigated by Mini-invasive Interventional Method
TANG Li-jun,WANG De-hang,WANG Wei-dong,GAO Xing-ya. The Hemodynamic Changes in the Rabbit Model of Acute Lung Injury Investigated by Mini-invasive Interventional Method[J]. Acta Universitatis Medicinalis Nanjing, 2001, 21(2): 129-131
Authors:TANG Li-jun  WANG De-hang  WANG Wei-dong  GAO Xing-ya
Affiliation:TANG Li-jun,WANG De-hang,WANG Wei-dong,GAO Xing-ya 1
Abstract:
Objective:To prepare the rabbit model of acute lung i njury induced by oleic acid and evaluate hemodynamic effects after injecting di fferent doses of oleic acid from the peripheral vein by a mini-invasive interve ntional method. Methods:Control group and oleic acid group were inje cted the same dose of normal saline and oleic acid from the peripheral vein resp ectively. The dosage was separeated in 4 times for injection, at first time the dosage was 0.06 ml/kg and the others were 0.04 ml/kg. The pulmonary arterial pre ssure, aortic pressure and heart rate were measured at 5, 10 min and 15 min afte r each injection. Results:The more dosage was injected, the slower was the heart rate and the lower was the aortic pressure, and the pulmonary arteria l pressure elevated first and then went down. Conclusion:The hemodynam ic changes can be investigated by the interventional method. It was significant at the cumulative dose of 0.06 ml/kg or 0.10 ml/kg.
Keywords:acute lung injury  rabbit  animal model  hemodynamic c hange  mini-invasive interventional method
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