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Large granular lymphocytic leukaemia after solid organ and haematopoietic stem cell transplantation |
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| Authors: | Hassan Awada Reda Z. Mahfouz Jibran Durrani Ashwin Kishtagari Deepa Jagadeesh Alan E. Lichtin Brian T. Hill Betty K. Hamilton Hetty E. Carraway Aziz Nazha Navneet S. Majhail Ronald Sobecks Valeria Visconte Matt Kalaycio Mikkael A. Sekeres Jaroslaw P. Maciejewski |
| Affiliation: | 1. Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA;2. Lymphoid Malignancies Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA;3. Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA;4. Blood and Marrow Transplant Program, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA;5. Leukaemia Program, Department of Hematology and Medical Oncology, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA |
| Abstract: | T-cell large granular lymphocytic leukaemia (T-LGLL) is a chronic clonal lymphoproliferative disorder of cytotoxic T lymphocytes which commonly occurs in older patients and is often associated with autoimmune diseases. Among 246 patients with T-LGLL seen at our institution over the last 10 years, we encountered 15 cases following solid organ or haematopoietic stem cell transplantation. Here, we studied the clinical characterization of these cases and compared them to de novo T-LGLL. This experience represented a clear picture of the intricate nature of the disease manifestation and the complexities of several immune mechanisms triggering the clonal expansion. |
| Keywords: | large granular lymphocytic leukaemia solid organ transplantation bone marrow transplantation |