283例脐血管穿刺诊断胎儿染色体异常临床分析

目的:评价超声引导下脐血管穿刺术在产前诊断中的应用,探讨胎儿染色体异常的临床高危因素,提高脐血管穿刺对胎儿异常染色体核型的检出率.方法:选取在我院超声引导下经腹脐血管穿刺并行染色体检查的孕妇283例,进行染色体核型分析,比较不同产前诊断指征组的异常染色体检出率及相关因素分析.结果:穿刺成功率100%,胎儿脐血管穿刺的主要并发症为穿刺点出血33例(11.66%),胎心心动过缓5例(1.77%).共检出异常染色体核型25例,检出率8.83%.发现夫妇中有染色体异常与胎儿染色体异常存在相关性(r=22.348,P=0.000).结论:超声引导下经腹脐血管穿刺抽取脐血在产前诊断中是较成熟有效的操作技术.夫妇双方有染色体异常是进行产前诊断的必要指征.

Clinical Study of Chromosomal Abnormalities by Puncturing Umbilical Cords

Objective:To evaluate the application of puncturing the umbilical cord under the ultrasound guidance in prenatal diagnosis,clinical high risk factors of fetal chromosomal abnormalities were discussed.Methods:283 pregnant women who had the percutaneous umbilical cord blood sampling were recruited and the karyotyping was done.The detection rate of chromosomal abnormalities and correlate factors in different subgroups of prenatal diagnosis were analyzed.Results:The success rate of puncture was 100%.Major compl...