| 贯叶连翘提取物和盐酸赖氨酸复方的镇痛作用研究 |
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| 引用本文： | 胡然,库宝善,朱素君,贾永蕊,张永鹤,姚海燕. 贯叶连翘提取物和盐酸赖氨酸复方的镇痛作用研究[J]. 中国组织工程研究与临床康复, 2003, 7(26): 3600-3601 |
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| 作者姓名： | 胡然 库宝善 朱素君 贾永蕊 张永鹤 姚海燕 |
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| 作者单位： | 北京大学医学部药理学系,北京市,100083 |
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| 摘 要： | 目的:研究贯叶连翘提取物和盐酸赖氨酸复方(贯叶连翘提取物与盐酸赖氨酸以质量比2∶1配比,简称赖金丝)的镇痛抗炎作用。方法:采用小鼠醋酸扭体实验、甲醛实验和热板实验。结果:赖金丝125,250和500mg/kg灌胃能:①显著减少小鼠扭体次数,抑制率分别为29%,32%和54%。②显著抑制甲醛引起的第2时相疼痛反应,分别使小鼠舔脚时间缩短至(23±20),(18±22)和(12±19)s。③显著减轻甲醛所致小鼠足跖水肿,小鼠左右足重量差值较阴性对照组(34±15)减轻至(16±15),(18±12)和(15±6)mg。但不能抑制甲醛引起的第1时相疼痛反应和小鼠热板反应。结论:赖金丝在125～500mg/kg剂量范围内对炎症性疼痛效果显著,能抑制皮下注射甲醛引起的水肿,可能在外周抑制炎症过程的某个环节。
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| 关 键 词： | 连翘 赖氨酸 镇痛 |
| 文章编号： | 1671-5926(2003)26-3600-02 |
| 修稿时间： | 2003-05-26 |
Study of analgesic effect of the complex of hypericum perforatum L.extract and lydine hydrochloride |
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| Ran Hu,Bao-Shan Ku,Su-Jun Zhu,Yong-Rui Jia,Yong-He Zhang,Hai-Yan Yao,Dep artment of pharmacolog,Peking University Health Science Center,Beijing ,Ch ina. Study of analgesic effect of the complex of hypericum perforatum L.extract and lydine hydrochloride[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2003, 7(26): 3600-3601 |
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| Authors: | Ran Hu Bao-Shan Ku Su-Jun Zhu Yong-Rui Jia Yong-He Zhang Hai-Yan Yao Dep artment of pharmacolog Peking University Health Science Center Beijing Ch ina |
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| Affiliation: | Ran Hu,Bao-Shan Ku,Su-Jun Zhu,Yong-Rui Jia,Yong-He Zhang,Hai-Yan Yao,Dep artment of pharmacolog,Peking University Health Science Center,Beijing 100083,Ch ina |
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| Abstract: | |
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| Keywords: | Laijinsi in the range of 125-500 mg/kg (ig)can inhibit inflammato ry pain and oedema induced by formaldehyde. It is upposed that Laijinsi might in hibit inflammation on peripheral level. |
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