| 5-氟尿嘧啶-偕二膦酸偶合物的合成及其初步骨靶向性实验 |
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| 引用本文： | 黄振,张国尧,蒋庆琳,曾建成,吴勇.5-氟尿嘧啶-偕二膦酸偶合物的合成及其初步骨靶向性实验[J].中国药物化学杂志,2005,15(6):363-364,368. |
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| 作者姓名： | 黄振 张国尧 蒋庆琳 曾建成 吴勇 |
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| 作者单位： | 1. 四川大学,华西药学院,四川,成都,610041
2. 四川大学华西医院,四川,成都,610041 |
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| 摘 要： | 以5-氟尿嘧啶为原料,经加成、缩合、催化氢解等3步反应合成得到一个新的5-氟尿嘧啶-偕二膦酸偶合物,其结构经1H-NMR、IR和MS确证,并采用羟磷灰石晶体吸附实验考察其骨靶向性,结果显示目标物有较好的骨靶向性.
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| 关 键 词： | 药物化学 化合物制备 化学合成 5-氟尿嘧啶-偕二膦酸偶合物 骨靶向 |
| 文章编号： | 1005-0108（2005）06-0363-02 |
| 收稿时间： | 2005-09-30 |
| 修稿时间： | 2005-09-30 |
Synthesis and preliminary bone-targeted test of bis(phosphonic acid)-5-fluorouracil conjugate |
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| HUANG Zhen,ZHANG Guo-yao,JIANG Qing-lin,ZENG Jian-cheng,WU Yong.Synthesis and preliminary bone-targeted test of bis(phosphonic acid)-5-fluorouracil conjugate[J].Chinese Journal of Medicinal Chemistry,2005,15(6):363-364,368. |
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| Authors: | HUANG Zhen ZHANG Guo-yao JIANG Qing-lin ZENG Jian-cheng WU Yong |
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| Institution: | 1. West China School of Pharmacy, Sichuan University, Chengdu 610041, China ; 2. West China Hospital of Sichuan University, Chengdu 610041, China |
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| Abstract: | A new bis(phosphonic acid)-5-fluorouracil conjugate was synthesized from 5-fluorouracil through 3-step reactions,including addition,condensation and catalytic hydrogenation.The chemical structure was(identified) by()~1H-NMR,IR and MS spectra and shows good bone-targeted ability in vitro via hydroxyapatite adhesion test. |
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| Keywords: | medicinal chemistry compound preparation chemical synthesis bis(phosphonic acid)-5-fluorouracil conjugate bone-target |
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