Is it time to reconsider initial antibiotic treatment strategies for severe urinary tract infections in Europe? |
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Authors: | J. R. Zahar M. Lecuit E. Carbonnelle F. Ribadeau-Dumas X. Nassif O. Lortholary |
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Affiliation: | UniversitéParis V, RenéDescartes, Hôpital Necker-Enfant Malades, Centre d'Infectiologie Necker Pasteur Service de Microbiologie and Service des Maladies Infectieuses et Tropicales, Paris, France |
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Abstract: | Until recently, most reported cases of bacteraemia caused by multidrug-resistant strains of Enterobacteriacae producing an extended-spectrum beta-lactamase (ESBL) in Europe have been nosocomial in origin. However, increasing numbers of reports of community-acquired bacteraemia and urinary tract infection caused by ESBL-producing microorganisms suggest that the geographical origin of patients should be taken into account as a risk-factor for possible ESBL production. Early identification of patients at high-risk of infection with ESBL-producing microorganisms, based on their geographical origin and travel history, should help to optimise initial antibiotic treatment strategies for severe urinary tract infections in Europe. |
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Keywords: | Antibiotic therapy bacteraemia extended-spectrum β-lactamase geographical origin risk-factor urinary tract infection |
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