不同剂量布托啡诺剖宫产术后硬膜外镇痛的研究

目的:观察不同剂量布托啡诺剖宫产术后硬膜外镇痛效果。方法:60例(ASAI～Ⅱ级)剖宫产病人随机分成3组,对照组(BM组)、实验组1(B1组)、实验组2(B2组)。镇痛药物为:BM组(n=20)0.1125%布比卡因+0.004%吗啡;B1组(n=20)0.1125%布比卡因+0.004%布托啡诺;B2组0.1125%布比卡因+0.006%布托啡诺。采用负荷量+持续剂量给药模式,持续剂量背景流速3ml/h。结果:①VAS、BCS评分在术后8h,BM组低于B1组,BM组与B2组无明显差异。B1组与B2组各项评分无明显差异。②并发症:各组恶心呕吐、搔痒及呼吸抑制的发生率差异无显著性。结论:0.1125%布比卡因+0.006%布托啡诺剖宫产术后硬膜外镇痛效果确切,但不良反应的发生率与0.1125%布比卡因+0.004%吗啡组相比无明显改善。

A study on postoperative epidural analgesia after caesarean section with different dose of butorphanol

Objective:To observe the analgesic effects with different dose of butorphanol for postoperative epidural analgesia after caesarean section.Methods:60 ASAI～Ⅱ cases undergone caesarean section were randomly divided into control group(group BM,n=20,mixture of 0.1125% bupivacaine and 0.004% morphine).No.1 experimental group(group B1,mixture of 0.1125% bupivacaine and 0.004% butorphanol) and No.2(group B2,n=20;mixture of 0.1125% bupivacaine and 0.006% butorphanol).The three groups were carried out by loading-continuous administration with continuous doses of 3 ml/h by a pump.Results:①VAS and BCS in group BM were lower than that in group B1 at 8 h during postoperative with no difference in B2.②The incidence of nausea and pruritus in group BM was equivalent to group B1 or B2.Conclusion:Epidural administration of 0.1125% bupivacaine and 0.006% butorphanol will provide analgesia for post-caesarean section,but that produces obvious adverse effects.