血清胱抑素C评价早期肾功能损害的临床意义探讨

目的 评价血清胱抑素C（Cys C）对早期肾功能损害诊断的临床意义.方法 应用免疫比浊法测定136例肾脏病患者血清Cys C浓度,用Jaffe法测定血清SCr.以内生肌酐清除率（Ccr）测得的肾小球滤过率（GFR）作为诊断评价的金指标,比较Cys C、SCr浓度与GFR的相关性,评估Cys C结果的临床敏感性、特异性和可靠性.结果 血清Cys C、SCr浓度与GFR均呈显著相关（P＜0.01）;以Cys C与GFR的相关程度最密切;且Cys C与SCr显著相关（P＜0.05）.结论 血清Cys C是一个准确、可靠的反映肾小球滤过功能的指标,对诊断肾脏病患者早期肾功能损害具有指导意义.

Clinical Significance of Serum Cystatin C in the Diagnosis of Early Renal Impairment

Objective To evaluate clinical significance of serum cystatin C （ Cys C ） in diagnosis of early renal impairment. Methods The serum Cys C levels of 136 patients with renal diseases were determined by immuno- turbidimetry, and serum ereatinine （SCr） were detected by Jaffe method. The glomerular filtration rate （GFR） measured by the method of endogenous creatinine clearance rate （Ccr） was used as golden standard, the corre- lation between GFR and the above two parameters were compared. The sensitivity, specificity and the reliability of Cys C were evaluated. Results The significant correlation was found between GFR, Cys C and Scr, and that the correlation between GFR and Cys C was the most strongest （ P 〈 0.01 ）. There was significant statistical difference between Cys C and SCr （ P 〈 0.05 ）. Conclusion Serum Cys C may be an accurate and reliable pa- rameter to reflect the GFR in patients with impaired renal function and it might have guidance significance in di- agnosis of early renal impairment.