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Immunoexpression of extracellular matrix proteins in human salivary gland development
Authors:Furuse Cristiane  Cury Patrícia Ramos  de Araújo Ney Soares  de Araújo Vera Cavalcanti
Affiliation:Department of Oral Pathology, S?o Leopoldo Mandic Dental Research Institute, Campinas, Brazil.
Abstract:
Immunoexpression of the extracellular matrix (ECM) proteins laminin, fibronectin, tenascin and types I, III and IV collagen was analyzed in the major and minor salivary glands of seven human fetuses at different gestational ages. The results showed the presence and localization of laminin, collagen IV and fibronectin around glandular structures at all stages of development. Tenascin was only detectable around excretory ducts. In the earliest stages of development, type I and type III collagen were presented as fine fibers delineating the glandular structures and delimiting the extension of the future lobule. As glandular development proceeded, the lobule was gradually filled with collagens and glandular tissue.
Keywords:development    extracellular matrix    human salivary gland    immunohistochemistry
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