三维适形放疗配合化疗治疗放疗后局部复发的非小细胞肺癌的疗效观察

目的探讨三维适形放疗+化疗治疗放疗后局部复发的非小细胞肺癌(NSCLC)的疗效。方法28例NSCLC常规外照射后局部复发患者,采用三维适形放疗(3DCRT)加全身化疗(NP方案化疗2周期)。结果28例患者全部完成治疗,4例完全缓解(CR),17例部分缓解(PR),5例稳定(NC),2例进展(PD)。总有效率(CR+PR)75.0%(21/28)。1、2年生存率分别为53.6%(15/28)、10.7%(3/28)。结论放疗后局部复发的NSCLC采用3DCRT合并NP方案化疗近期疗效满意,局部疗效好,远期疗效及晚期并发症有待观察。

Combined Three Dimensional-conformal Radiotherapy(3DCRT) and Chemotherapy Treat Local-recurrence Non-small Cell Lung Cancer(NSCLC) After Radiotherapy

Objective To evaluate the efficacy of combined 3DCRT and chemotherapy treatment to local-recurrent NSCLC after radiotherapy.Methods 28 cases of local-recurrent patients after conventional external radiotherapy accepted chemotherapy and 3DCRT. All patients were accepted NP plan two cycles. Results All the 28 patients had fulfilled the treatment, and the complete response rates(4/28); partial response rates(17/28); no change rates(5/28) and 2 proceed diseases(2/28), with a total responsibility rates of 75.0% (21/28).The 1 and 2 years of survival rates were 53.6% (15/28) and 10.7% (3/28). Conclusion Combined 3DCRT and NP plan should be considered as an effective and feasible approach in the treatment of local-recurrence NSCLC patients, the partial curative effect is good. Long-term curative effect and late period complication await further study.