The relationship between dietary fat intake and risk of colorectal cancer: evidence from the combined analysis of 13 case-control studies |
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| Authors: | Geoffrey R. Howe Kristan J. Aronson Enrique Benito Roberto Castelleto Jacqueline Cornée Stephen Duffy Richard P. Gallagher José M. Iscovich Jiao Deng-ao Rudolf Kaaks Gabriel A. Kune Susan Kune Hin P. Lee Marion Lee Anthony B. Miller Ruth K. Peters John D. Potter Elio Riboli Martha L. Slattery Dimitrios Trichopoulos Albert Tuyns Anastasia Tzonou Lyndsey F. Watson Alice S. Whittemore Anna H. Wu-Williams Zheng Shu |
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| Affiliation: | (1) Division of Epidemiology, Columbia University School of Public Health, New York, USA;(2) Community Health and Epidemiology, Queens University, Kingston, Canada;(3) Unitat d'Epidemiologia i Registre de Cancer de Mallorca, Palma de Mallorca, Spain;(4) Department of Pathology, La Plata National University, La Plata, Argentina;(5) INSERM, Lyon, France;(6) Biostatistics Unit, Medical Research Council, Cambridge, UK;(7) Cancer Control Agency of British Columbia, Vancouver, Canada;(8) Ministry of Health Jerusalem, Israel Center for Registration of Cancer and Allied Diseases, Israel;(9) Chejiang Medical University Hangcho, People's Republic of China;(10) International Agency for Research on Cancer, Lyon, France;(11) Department of Surgery, University of Melbourne, Melbourne, Australia;(12) Department of Community, Occupational and Family Medicine, National University of Singapore, Singapore, Singapore;(13) Department of Epidemiology and Biostatistics, University of California, San Francisco, USA;(14) Department of Preventive Medicine and Biostatistics, University of Toronto, Toronto, Canada;(15) Department of Preventive Medicine, University of Southern California, School of Medicine, Los Angeles, USA;(16) Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA;(17) Department of Oncological Sciences, University of Utah, Salt Lake City, USA;(18) Department of Epidemiology, Harvard School of Public Health, Boston, USA;(19) Department of Hygiene and Epidemiology, University of Athens, Athens, Greece;(20) Department of Health Research and Policy, Division of Epidemiology, Stanford University, Stanford, USA |
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| Abstract: | ![]()
The objective of this study was to examine the effects of the intakeof dietary fat upon colorectal cancer risk in a combined analysis of datafrom 13 case-control studies previously conducted in populations withdiffering colorectal cancer rates and dietary practices. Original datarecords for 5,287 cases of colorectal cancer and 10,470 controls werecombined. Logistic regression analysis was used to estimate odds ratios (OR)for intakes of total energy, total fat and its components, and cholesterol.Positive associations with energy intake were observed for 11 of the 13studies. However, there was little, if any, evidence of anyenergy-independent effect of either total fat with ORs of 1.00, 0.95, 1.01,1.02, and 0.92 for quintiles of residuals of total fat intake (P trend =0.67) or for saturated fat with ORs of 1.00, 1.08, 1.06, 1.21, and 1.06 (Ptrend = 0.39). The analysis suggests that, among these case-control studies,there is no energy-independent association between dietary fat intake andrisk of colorectal cancer. It also suggests that simple substitution of fatby other sources of calories is unlikely to reduce meaningfully the risk ofcolorectal cancer. |
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| Keywords: | Case-control studies colorectal neoplasms dietary fat energy |
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