甲氨蝶呤联合米非司酮治疗不同血β-人绒毛膜促性腺激素水平异位妊娠的临床效果

目的 研究甲氨蝶呤联合米非司酮治疗不同血β-人绒毛膜促性腺激素（β-HCG）浓度异位妊娠的临床效果。方法 选取本院2011年3月~2014年3月收治的86例异位妊娠患者为研究对象,采用甲氨蝶呤＋米非司酮治疗,根据患者不同血β-HCG浓度将其分为A组（〈2000 U/L）和B组（≥2000 U/L）,比较两组治疗效果及不良反应情况。结果 A组治愈率为91.30%,高于B组的70.00%,差异有统计学意义（P〈0.05）;A组不良反应发生率为13.04%,低于B组的32.50%,差异有统计学意义（P〈0.05）;A组患者症状消失时间、尿β-HCG转阴时间及血β-HCG恢复正常时间均明显短于B组,差异有统计学意义（P〈0.05）。结论 甲氨蝶呤联合米非司酮治疗异位妊娠的效果明确,且血β-HCG浓度越低疗效越明显。

Clinical effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy on different blood beta human chorionic gonadotrophin levels

Objective To research clinical effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy on different blood beta human chorionic gonadotrophin （β-HCG）levels. Methods 86 cases of patients with ectopic pregnancy in our hospital from March 2011 to March 2014 were selected as study objects,methotrexate and mifepristone were used in all patients,study objects were divided into group A（〈2000 U/L）and group B（≥2000 U/L）depending on the concentration of serum β-HCG.The effect and adverse reaction in two groups was compared respectively. Results Cure rate of group A was 91.30%,higher than that of group B （70.00%）,with statistical difference（P〈0.05）.Incidence rate of adverse reaction in group A was 13.04%,lower than that in group B （32.50%）,with statistical difference （P〈0.05）.Symptom disappear time,β-HCG of urine and blood β-HCG returned to normal time in group A was significantly shorter than that in group B respectively,with statistical difference（P〈0.05）. Conclusion The effect of methotrexate combined with mifepristone in the treatment of ectopic pregnancy is clear,and the lower the blood concentration of β-HCG,the more obvious curative effect.