艾司西酞普兰治疗脑卒中后抑郁的对比研究

目的:探讨艾司西酞普兰治疗脑卒中后抑郁障碍的疗效和安全性。方法:将68例脑卒中后抑郁的患者分为艾司西酞普兰组(36例)和氟西汀组(32例),所有患者均采用艾司西酞普兰或氟西汀胶囊口服用药。分别在用药前和用药后1、2、4、8周末采用汉密尔顿抑郁量表(HAMD)评定患者的临床疗效、采用治疗中出现的症状量表(TESS)评定患者的不良反应。结果:在治疗第1周末时艾司西酞普兰组患者的HAMD总分低于氟西汀组(P<0.05),而在第2、4、8周两组患者比较差异无统计学意义(P>0.05)。两组患者均无明显药物不良反应,不良反应发生率无统计学意义。结论:艾司西酞普兰与氟西汀治疗脑卒中后抑郁疗效相当,但艾司西酞普兰起效快。

Comparative study of Escitalopram and fluoxetine in treatment of post-stroke depression

Objective： To explore clinical effect and safety of Escitalopram and Fluoxetinein treatment of post- stroke depression. Methods： A total of 68 patients with post- stroke depression were divided into Escitalopram group（ n = 36,orally took Escitalopram） and Fluoxetine group（ n = 32,orally took Fluoxetine）,and they were treated for 8weeks. The clinical effect was evaluated with Hamilton depression scale（ HAMD） and the side effects were evaluated with treatment emergent symptom scale（ TESS） before and 1,2,4,and 8 weeks after the treatment. Results： 1 week after the treatment,the total HAMD score of Escitalopram group was lower than that of Fluoxetine group（ P〈0. 05）,however,2,4,and 8 weeks after the treatment,there were no statistical differences in the total HAMD score between the two group（ P〉0. 05）. The severe side effects were not found in both groups,and the incidence rate of side effects was not significantly different between the two groups. Conclusions： The clinical effects of Escitalopram and Fluoxetine in the treatment of post- stroke depression patients are similar,but Escitalopram has afaster effect than Fluoxetine.