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| 慢性髓系性白血病DNA甲基化及与临床相关性研究进展 | |
| 引用本文： | 唐勇,胡钧培. 慢性髓系性白血病DNA甲基化及与临床相关性研究进展[J]. 中国实验血液学杂志, 2008, 16(6): 1482-1486 |
| 作者姓名： | 唐勇 胡钧培 |
| 作者单位： | 上海交通大学医学院附属第九人民医院,血液科,上海,200011 |
| 摘 要： | 各种类型肿瘤均有特征性的DNA甲基化模式。在慢性髓系白血病（CML）中，对DNA甲基化改变的主要研究内容包括：①致癌基因的低甲基化，②肿瘤抑制基因的超甲基化和③融合基因的超甲基化。本文就CMLDNA甲基化变化及其在CML临床分期、预后评估中的作用等方面作一综述，阐明CML与基因DNA甲基化的关系。 |
| 关 键 词： | 慢性髓细胞性白血病 DNA甲基化 低甲基化 超甲基化 |
New Insight into DNA Methylation in CML and Its Effect on Clinical outcome-Review |
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| TANG Yong,HU Jun-Pei. New Insight into DNA Methylation in CML and Its Effect on Clinical outcome-Review[J]. Journal of experimental hematology, 2008, 16(6): 1482-1486 | |
| Authors: | TANG Yong HU Jun-Pei |
| Affiliation: | TANG Yong,HU Jun-Pei Department of Hematology,The Ninth People Hospital,Shanghai Jiaotong University Medical College,Shanghai 200011,China |
| Abstract: | All kinds of tumors have their specific DNA methylation patterns.The study of DNA methylation changes in chronic myelogeneous leukemia includes(1) the hypomethylation of carcinogenic gene,(2) the hypermethylation of tumor-suppressing gene,and(3) the hypermethylation of fusion gene.In this paper,DNA methylation change in chronic myeloid leukemia(CML) and its role in clinical stages and evaluation of prognosis were reviewed so as to illuminate the relationship between DNA methylation and CML. |
| Keywords: | chronic myelogeneous leukemia DNA methylation hypomethylation hypermethylation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |