藏药四臣止咳颗粒剂的药效学研究

目的：观察藏药四臣止咳颗粒剂的药效作用及机理。方法：采用咳嗽、炎症、发热等动物模型观察其止咳、抗炎、解热作用。结果：该制剂在6.7g生药/kg、13.4g生药/kg、26.8g生药/kg剂量下,各剂量组均能显著的抑制浓氨水诱发的小鼠咳嗽（P〈0.01）,中、大剂量组均能显著的抑制二氧化硫诱发的小鼠咳嗽（P〈0.01）;在8.14g生药/kg、16.28g生药/kg剂量下能显著的抑制枸橼酸诱发的豚鼠咳嗽（P〈0.01）,对大鼠和小鼠的急性炎症反应有抗炎作用,对家兔发热有轻度的解热作用。结论：证实了四臣止咳颗粒剂的止咳作用及其机理。

Pharmacodynamic research on antitussive effect of Tibet medicine Si Chen Zhi Ke Granule

Objective: To observe the pharmacodynamic function of Tibet medicine Si Chen Zhi Ke Granule and its mechanism.Methods: Animal model of cough,inflammation and fever were used to investigate the pharmacodynamic action.Results: This medicine could evidently supress cough induced by strong ammonia in mice at the dosage of crude drug 6.7g /kg,crude drug 13.4g /kg and crude drug 26.8g /kg(P<0.01),evidently suppress cough induced by SO2 in mice at the medium and large dosage(P<0.01),evidently supress cough induced by Citric acid in Guinea Pigs at the dosage of crude drug 8.14g /kg,crude drug 16.28g/kg(P<0.01.The anti-inflammation effect was obvious on the mice and rats.It also had mild antipyretic effect on fevered rabbits.Conclusion: The antitussive effect and mechanism of Tibet medicine Si Chen Zhi Ke Granule were confirmed.