Promotion and prevention of autoimmune disease by CD8+ T cells |
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Affiliation: | 1. The Jackson Laboratory, Bar Harbor, Maine, USA;2. Department of Medicine, Division of Dermatology, Vanderbilt University, Nashville, Tennessee, USA;3. Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada;4. Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts, USA;5. Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA;1. University of L''Aquila, Department of Biotechnological and Applied Clinical Sciences, Clinical Pathology, L''Aquila, Italy;2. University of L''Aquila, Department of Biotechnological and Applied Clinical Sciences, Rheumatology Unit, L''Aquila, Italy;3. Division of Allergy and Clinical Immunology, Bnai-Zion Medical Center, Faculty of Medicine, Technion, Haifa, Israel;1. Type 1 Diabetes Centre, Infectivology and Clinical Trials Research Department, Children''s Hospital Bambino Gesù, Rome, Italy;2. Section of Pharmacology, Department of Medicine, University of Perugia, Italy |
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Abstract: | Until recently, little was known about the importance of CD8+ T effectors in promoting and preventing autoimmune disease development. CD8+ T cells can oppose or promote autoimmune disease through activities as suppressor cells and as cytotoxic effectors. Studies in several distinct autoimmune models and data from patient samples are beginning to establish the importance of CD8+ T cells in these diseases and to define the mechanisms by which these cells influence autoimmunity. CD8+ effectors can promote disease via dysregulated secretion of inflammatory cytokines, skewed differentiation profiles and inappropriate apoptosis induction of target cells, and work to block disease by eliminating self-reactive cells and self-antigen sources, or as regulatory T cells. Defining the often major contribution of CD8+ T cells to autoimmune disease and identifying the mechanisms by which they alter the pathogenesis of disease is a rapidly expanding area of study and will add valuable information to our understanding of the kinetics, pathology and biology of autoimmune disease. |
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Keywords: | Autoimmune disease CD8+ T cell Tolerance AIHA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0030" }," $$" :[{" #name" :" text" ," _" :" autoimmune hemolytic anemia ALPS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0040" }," $$" :[{" #name" :" text" ," _" :" autoimmune lymphoproliferative syndrome APC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" antigen presenting cells CTL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" cytotoxic T lymphocytes EAE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" experimental autoimmune encephalomyelitis HLA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" human leukocyte antigen LCMV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" lymphocytic choriomeningitis virus MBP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" myelin basic protein MOG" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" myelin oligodendrocyte glycoprotein MPP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" myelin proteolipid protein MHC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" major histocompatibility complex MS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" multiple sclerosis RA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" rheumatoid arthritis SLE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" systemic lupus erythematosus T1D" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" type 1 diabetes Tc" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" cytokine producing CD8+ effectors TCR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" T cell receptor Treg" },{" #name" :" keyword" ," $" :{" id" :" kwrd0200" }," $$" :[{" #name" :" text" ," _" :" regulatory T cell TRA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0210" }," $$" :[{" #name" :" text" ," _" :" tissue restricted antigens |
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