| 深海曲霉属真菌Aspergillus insulicola的化学成分研究 |
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| 引用本文： | 赵伟博,畅文军,戴好富,吕芳,曾艳波.深海曲霉属真菌Aspergillus insulicola的化学成分研究[J].中国海洋药物,2023,42(6):61-66. |
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| 作者姓名： | 赵伟博 畅文军 戴好富 吕芳 曾艳波 |
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| 作者单位： | 北京理工大学生命学院,中国热带农业科学院热带生物技术研究所海南省海洋生物资源功能性成分研究与利用重点实验室,中国热带农业科学院热带生物技术研究所海南省海洋生物资源功能性成分研究与利用重点实验室,北京理工大学生命学院生物医药成分分离与分析北京市重点实验室,中国热带农业科学院热带生物技术研究所海南省海洋生物资源功能性成分研究与利用重点实验室 |
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| 基金项目： | 国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 摘 要： | 目的 对深海沉积物来源真菌Aspergillus insulicola中的化学成分进行研究。方法 采用正反向硅胶柱色谱、高效液相色谱等方法对其大米发酵产物进行分离提纯；通过质谱、核磁共振等波谱学方法并结合文献数据鉴定其结构。结果 从海洋真菌A. insulicola大米发酵产物的乙酸乙酯提取物中共分离鉴定了9个化合物,其结构分别为：aspermicrone C(1)、aspermicrone B(2)、epicolactone(3)、F14945-C(4)、6,7-dihydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one(5)、5,6-dihydroxy-7- methoxy-4-methylisobenzo- furan-1(3H)-one(6)、3-methoxyepicoccone(7)、3,4-dihydroxyphenylacetic acid methyl ester(8)和glycerol-1- monooleate(9)。结论 化合物5为新的天然产物,其余化合物均为已知化合物。生物活性测试结果显示化合物1和2对火龙果黑斑病菌有一定的抑制作用。
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| 关 键 词： | 海洋真菌 Aspergillus insulicola 次级代谢产物 抑菌活性 |
| 收稿时间： | 2022/8/19 0:00:00 |
| 修稿时间： | 2022/10/18 0:00:00 |
Chemical constituents from marine-derived fungus Aspergillus insulicola |
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| ZHAO Wei-bo,CHANG Wen-jun,DAI Hao-fu,LV Fang and ZENG Yan-bo.Chemical constituents from marine-derived fungus Aspergillus insulicola[J].Chinese Journal of Marine Drugs,2023,42(6):61-66. |
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| Authors: | ZHAO Wei-bo CHANG Wen-jun DAI Hao-fu LV Fang and ZENG Yan-bo |
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| Institution: | Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals,School of Life Science,Beijing Institute of Technology,Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou,Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou,Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals,School of Life Science,Beijing Institute of Technology,Hainan Provincial Key Laboratory for Functional Components Research and Utilization of Marine Bio-resources,Institute of Tropical Bioscience and Biotechnology,Chinese Academy of Tropical Agricultural Sciences,Haikou |
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| Abstract: | Objective To study the chemical constituents of the marine-derived fungus Aspergillus insulicola which was isolated from deep-sea sediment. Methods All compounds were separated and purified by silica gel column chromatography and high-performance liquid chromatography, and the structures of isolated compounds were identified by mass spectrometry and nuclear magnetic resonance combined with literature data. Results Nine compounds were isolated from ethyl acetate extract of marine-derived fungus A. insulicola, and their structures were identified as aspermicrone C (1), aspermicrone B (2), epicolactone (3), F14945-C (4), 6,7-dihydroxy-5-methoxy-4-methylisobenzofuran-1(3H)-one (5), 5,6-dihydroxy-7-methoxy-4-met |
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| Keywords: | Marine fungi Aspergillus insulicola Secondary metabolites Antibacterial activity |
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