| 外源性3’,5’环腺苷酸对肝癌-H_(22)腹水型癌细胞Mg~(++),(Na~+-K~+)-ATP酶、磷酸二酯酶影响的观察 |
| |
| 引用本文： | 吕桂芝,黄衍川,高燕,汪堃仁. 外源性3’,5’环腺苷酸对肝癌-H_(22)腹水型癌细胞Mg~(++),(Na~+-K~+)-ATP酶、磷酸二酯酶影响的观察[J]. 解剖学报, 1987, 0(3) |
| |
| 作者姓名： | 吕桂芝 黄衍川 高燕 汪堃仁 |
| |
| 作者单位： | 北京市肿瘤防治研究所细胞生物学室，北京市肿瘤防治研究所细胞生物学室，北京市肿瘤防治研究所细胞生物学室，北京市肿瘤防治研究所细胞生物学室 |
| |
| 摘 要： | 本实验通过外源性3′,5′环腺苷酸和茶碱对小白鼠肝癌-H_(22)腹水型癌细胞的连续作用,观察到癌细胞的增殖受到明显抑制,伴随有癌细胞膜表面Mg~(++)-ATP酶、(Na~+-K~+)-ATP酶以及磷酸二酯酶活性明显下降;酶活性变化与膜表面微绒毛的变化,有一定平行关系。
|
| 关 键 词： | Mg~(++) (Na~+K~+)-ATP酶 cAMP-磷酸二酯酶 3' 5'环腺苷酸 微绒毛 细胞 化学 扫描电镜 |
ELECTRON MICROSCOPIC OBSERVATION OF THE CYTOCHEMICAL CHANGES OF Mg~(++), (Na~+-K~+)- ATPase, cAMP-PDE OF THE EFFECT OF 3'''', 5''''- cAMP ON HEPATOMA-22 ASCITIC TUMOR CELLS IN VIVO |
| |
| Lu Guizhi,Huang Yanchuan,Gao Yan,Wang Kunren. ELECTRON MICROSCOPIC OBSERVATION OF THE CYTOCHEMICAL CHANGES OF Mg~(++), (Na~+-K~+)- ATPase, cAMP-PDE OF THE EFFECT OF 3'''', 5''''- cAMP ON HEPATOMA-22 ASCITIC TUMOR CELLS IN VIVO[J]. Acta Anatomica Sinica, 1987, 0(3) |
| |
| Authors: | Lu Guizhi Huang Yanchuan Gao Yan Wang Kunren |
| |
| Abstract: | The experiment was carried out on Hepatoma-22 ascitic tumor cells of mice in vivo. Daily injection of 2 mg cAMP with 1 mg theophylline into the peritoneal cavity for 7 and 8 days, then these animals were sacrificed. We found that cAMP with theophylline inhibit the growth of tumor cells of Hepatoma-22 ascitic and decrease the activity of Mg~(++), (Na~+-K~+)-ATPase and cAMP-PDE on the cell surface of H-22 tumor cells of mice by cytochemical electron microscopy. Exogenic cAMP and theophlline decrease the activities of these enzymes and elevate the intracellular content of cAMP. These may indicate the reversion transformation of the cancer cell. |
| |
| Keywords: | Mg~(++) (Na~(+)-K~(+))-ATPase cAMP-PDE 3' 5'-cAMP Microvilli Cytochemistry Electron microscope |
| 本文献已被 CNKI 等数据库收录！ |
|
