脑卒中急性期患者血清和脑脊液游离氨基酸水平的研究

目的 探讨脑卒中急性期患者血清和脑脊液（ＣＳＦ）中游离氨基酸（ＦＡＡ）含量变化戌临床的关系。方法 对２８例脑出血和３０例脑梗死患者于急性期测定血清十种氨基酸（ＡＡ）含量,选择６５例正常人作为对照组：对１６例脑出血急性期患者和１２例正常人测定ＣＳＦ中十种ＡＡ含量。结果 （１）脑梗死组和脑出血组血清中谷氨酸（Ｇ１ｕ）、门冬氨酸（Ａｓｐ）含量显著高于对照组（Ｐ〈０．０１）,牛磺酸（Ｔａｕ）、甘氨到（Ｇ１

Changes of free fmino acids in serum and cerebral spind fluid in patients with acute stroke

Objactive: To investigate the changes of free Aminoacid in srum and cerebral spinal fluid (CSF) in patients with acrte stroke. Methods: The levels often kind of amino acids (AA) in serum andcsf were measured in 58 patients with acute stroke and 65 normalpersons. Results: (1) The levels of glutmate (Glu) and aspanate (Asp) inserum were singnificantly higher in acute stroke patients than those in controlgroup (P<0 01). (2)The serum levels of taurine and glscine were lover in patients than those in control group.(3)The CSF levels of Glu and Asp in patients with crebral heamorrhage were significantly higher than those in control group. Conclusions: Our finding suppoted the theors that exciotoxity of Aaplay a important role in brain injure in acute stroke.