肥厚型心肌病患者左室心肌纵向运动功能的组织多普勒评价

目的 :明确定量组织速度成像技术 (QTVI)评价肥厚型心肌病 (HCM )患者左心室局部收缩功能的价值。方法 :应用QTVI离线分析 3 1例HCM患者和 2 0例正常对照组左心室长轴方向各心肌节段的速度曲线 ,测量收缩峰值速度和峰值时间 ,计算同一水平不同心肌节段的平均峰值速度 (Vs)和峰值时间 (Ts)。结果 :梗阻型与非梗阻型HCM患者二尖瓣环、左心室基底部、中部及近心尖部各水平Vs均降低 ,Ts均延长 ,但二者差异无显著性意义 ,分别与对照组相比差异均有极显著性意义 (P <0 .0 1)。结论 :HCM患者尽管左心室射血分数正常 ,但左心室长轴方向各心肌节段收缩功能受损 ,QTVI能够准确定量评价HCM患者左心室局部收缩功能。

Assessment of left ventricular myocardial systolic motion along the longitudinal axis in patients with hypertrophic cardiomyo- pathy by Doppler tissue imaging

Objective:To determine the value of the quantitative tissue velocity imaging (QTVI) for the evaluation of the left ventricular regional systolic function in patients with hypertrophic cardiomyopathy (HCM).Methods:Off line profiles of the left ventricular regional systolic velocity along long axis in 31 HCM patients and 20 healthy subjects were analyzed by QTVI.The regional myocardial systolic peak velocities and times from the electrocardiographic Q wave to the peak of the systolic wave of each segment were measured.The mean peak velocities (Vs) and times (Ts) of different segments from the same level were calculated.Results:Vs was lower and Ts was longer at each level including mitral annular,basal,middle and apical segments in the HCM patients than in the healthy subjects ( P <0.01).But there were no significant differences in Vs and Ts between obstructive and non obstructive groups in HCM patients.Conclusion:The left ventricular myocardial contractility along the longitudinal axis is impaired although left ventricular ejection fraction is normal in HCM patients,suggesting that QTVI can assess accurately left ventricular regional systolic function in HCM patients.