老年冠心病患者血小板α颗粒膜蛋白水平的测定

目的：探讨血浆血小板α颗粒膜蛋白（GMP－140）水平的变化在老年冠心病中的意义。方法：用放免法测定24例老年冠心病和20例正常老年人的血浆GMP－140水平，同时测定末梢血小板（Plt）计数，血浆凝血酶原时间（PT）及心肌酶学。结果：急性心肌梗死（AMI）和不稳定性心绞痛（UAP）患者血浆GMP－140明显增高，GMP－140与心肌酶学及心肌梗死和心绞痛缺血面积均呈正相关。结论：GMP－140是AMI和UAP病情监测和预后的重要指标。

Plasma level of GMP-140 in old patients with cor onary atherosclerotic heart disease

Objective To discuss the significance of plasma level changes GMP 40 in old patients with coronary atherosclerotic heart disease(CAHO).Methods The plasma level of GMP 40 was measured among CAHD group( n =24) and control group( n =20) using radioimmunoassay.Platelet(PLT),plasma prothrombin time(PT) and myocardial enzymes were measured too.Results The plasma level of GMP 140 was much higher in the acute myocardial infarction(AMI) and unlimited angina pectoris(UAP) group than that in the control group( P <0 05).There was a correlation between plasma level of GMP 140 and the change of myocardial enzymes.as well as the ischemic area of AMI and UAP.Conclusions Plasma level of GMP 140 might be a important indicator to observe the change of disease and the prognostic of disease.