疏血通与丹参对脑梗死患者及其高危人群血液流变学影响的Meta分析

目的:比较疏血通与丹参在改善脑梗死患者及其高危人群血流状态的差异,为临床用药提供循证医学依据。方法:通过检索2000-2011年国内发表的文献,按纳入排除标准筛选,得到符合研究条件的文献13篇,用Meta分析方法处理文献中的数据。结果:疏血通组与丹参组比较:全血高切黏度(mPa.s):WMD=-0.53,95%CI(-0.76,-0.31),P<0.05;全血低切黏度(mPa.s):WMD=-1.40,95%CI(-2.05,-0.74),P<0.05;血浆黏度(mPa.s):WMD=-0.27,95%CI(-0.39,-0.15),P<0.05;纤维蛋白原(g/L):WMD=-0.75,95%CI(-0.97,-0.52),P<0.05;红细胞压积:WMD=-0.05,95%CI(-0.08,-0.01),P<0.05。结论:疏血通对血液流变学各项指标的影响均优于丹参,但文献的异质性较大。

A Meta-analysis for hemorrheologic parameters in patients with cerebral infarction or high risk population treated by Shuxuetong or Danshen

AIM: To compare effects of Shuxuetong on hemorrheologic parameters to that of Danshen in patients with cerebral infarction or high risk population,so that evidences in Evidence-based Medicine can be provided for clinical pharmacotherapy.METHODS: Thirteen articles corresponding to our researching condition were searched out by retrieving and screening domestic articles from 2000 to 2011 according to the criterion for including or excluding articles.The data were processed by the method of meta-analysis.RESULTS:A comparison between Shuxuetong versus Danshen: HS P<0.05];LS P<0.05];PV P<0.05];FIB P<0.05];HCT P<0.05].CONCLUSION: The improvement effects of Shuxuetong on hemorrheologic parameters are better than that of Danshen,even though serious heterogeneity exists among the selected articles.