不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响

目的:观察不同剂量阿托伐他汀对2型糖尿病患者心血管并发症的影响.方法:将150例2型糖尿病患者随机分为3组,对照组50例、常规降脂组50例(阿托伐他汀20 mg/d)、强化降脂组50例(阿托伐他汀40 mg/d).各组常规治疗包括抗血小板治疗和降糖(药物和/或胰岛素)治疗.均随访3年,观察各治疗组心血管并发症的发生情况,评价治疗效果.结果:与对照组相比,常规降脂组和强化降脂治疗后组TC、低密度脂蛋白-胆固醇(LDL-C)显著下降(P＜0.01),高密度脂蛋白-胆固醇(HDL-C)显著升高(P＜0.01).常规降脂组与强化降脂组治疗后比较,TC、LDL-C下降程度和HDL-C升高程度比较差异有统计学意义(P＜0.01).3年内主要心血管并发症与对照组相比,强化降脂组与常规降脂组比例明显降低(P＜0.05),且强化降脂组较常规降脂组心血管并发症发生比例明显降低(P＜0.05).结论:阿托伐他汀能显著减少2型糖尿病患者心血管并发症的发生,且强化降脂治疗效果更佳,无明显不良反应.

Effect of different doses of atorvastatin on cardiovascular complications in patients with type 2 diabetes

AIM: To investigate the effect of different doses of atorvastatin on cardiovascular complications in patients with type 2 diabetes.METHODS: 150 cases of type 2 diabetes patients were randomly divided into three groups,control group,conventional lipid-lowering group(atorvastatin 20 mg/d),intensive lipid-lowering group 50 cases(atorvastatin 40 mg/d)(n=50).The conventional therapies in three groups including antiplatelet therapy and hypoglycemic therapy(drugs and/or insulin).All groups were followed up for 3 years,investigate the effect between three groups in cardiovascular complications.RESULTS:Compared with control group,after treatment,the levels of TC and LDL-C were decreased and the levels of HDL-C were increased in conventional lipid-lowering group and intensive lipid-lowering group(P<0.01).After treatment,the TC,LDL-C decreased level and the HDL-C elevated level between conventional lipid-lowering group and intensive lipid-lowering group showed significantly difference(P<0.01).Compared with the control group,the proportion of major cardiovascular complications in 3 years was decreased significantly in the intensive lipid-lowering group and conventional lipid-lowering group(P<0.05).Compared with the conventional lipid-lowering group,the proportion of cardiovascular complications in the intensive lipid-lowering group was decreased significantly(P<0.05).CONCLUSION: Atorvastatin can decrease the cardiovascular complications in patients with type 2 diabetes,the effect of intensive lipid-lowering is better,and has no adverse reaction.