急性期精神分裂症转换帕利哌酮治疗的疗效及安全性

目的:对接受足疗程奥氮平单一治疗无效的急性期精神分裂症住院患者,逐步替换为帕利哌酮缓释片单一治疗后,观察其疗效和不良反应,以及对患者个人和社会功能的改善作用。方法:将45例受试者随机分为两组,研究组23例,由原先的奥氮平替换为帕利哌酮缓释片治疗6周;对照组22例,由原先的奥氮平替换为利培酮治疗6周。治疗前后分别用阳性与阴性症状量表(PANSS)、个人与社会功能量表(PSP)和不良反应量表(TESS)评价疗效和不良反应。结果:研究组PANSS总分、阳性症状分、阴性症状分和一般精神病理分自基线降低,以及PSP总分自基线升高均具有统计学意义(P<0.01)。研究组发生失眠、嗜睡、锥体外系不良反应(EPS)、血清催乳素升高各1例,但均可耐受。结论:对于奥氮平治疗无效的急性期精神分裂症患者,替换为帕利哌酮缓释片治疗或能安全有效地控制阳性/阴性症状,且明显改善患者的个人和社会功能。

Efficacy and safety of paliperidone extended-release tablets as substituting medication in acute patients with schizophrenia

AIM: To evaluate the efficacy,safety and effect on personal and social function of paliperidone extended-release tablets(paliperidone ER) as substitution in inpatients experiencing an acute episode of schizophrenia,and unresponsive to prior medications of olanzapine besids.METHODS: Forty-five patients enrolled were assigned to receive paliperidone ER or risperidone for 6 weeks,meanwhile their prior medications of olanzapine were slowly tapered off within first 2 weeks.Positive and Negative Symptom Scale(PANSS) was used to assess the efficacy,Personal and Social Performance Scale(PSP) for social function,Treatment Emergent Symptom Scale(TESS) for tolerability and safety.RESULTS:PANSS total and PANSS factors scores significantly decreased from baseline to end point in paliperidone ER treatment group(P<0.01),moreover,significant improvements in mean PSP scale scores were observed(P<0.01).Paliperidone ER treatment was associated with low incidence of adverse events including insomnia,somnolence,extrapyramidal disorder,increased serum prolactin concentration,which could be well tolerated.CONCLUSION: This study demonstrated that paliperidone ER,as substitution for olanzapine combines consistent efficacy in significantly improving the symptoms of schizophrenia and personal and social functioning with a favorable safety profile,may provide a valuable new alternative for schizophrenia.