生长激素治疗肝硬化低蛋白血症34例疗效观察

目的观察重组人生长激素(r-hGH)对肝硬化患者蛋白质代谢的影响。方法对68例肝硬化患者在保证热量的综合治疗前提下,随机分为r-hGH组及对照组。观察两组患者治疗前后的临床症状,检测治疗前、治疗后、停药2周后血清白蛋白、肝肾功能等指标的变化,检测治疗前内源性生长激素水平。结果肝硬化患者血清内源性生长激素水平升高[(15.8±3.2)ng/L],治疗10d后,患者食欲不振、腹胀、乏力、恶心等症状改善率高于对照组(P<0.05,P<0.01,P<0.01,P<0.05);治疗后及停药2周后血清白蛋白明显升高[分别为(31.9±4.2)g/L、(32.4±2.8)g/L],肝肾功能等指标无明显变化。结论在综合治疗基础上,使用r-hGH能迅速改善肝硬化患者的症状,改善低蛋白血症和营养状况,无明显不良反应。

Clinical study of treatment with recombining human growth hormone in liver cirrhosis patients with hypoalbuminemia

Objective To study the effect of treatment with recombining human growth hormone(r-hGH) in liver cirrhosis patients with hypoalbuminemia.Methods With integrating treatment(no blood products,albumin,albumin promoting drugs),68 liver cirrhosis patients were divided into r-hGH group and control group.The change of clinic symptoms,serum albumin,liver functions,kidney functions were observed before treatment,in treatment stopping and in 2 weeks after treatment.The levels of endogenesis r-hGH were examined before treatment.Results The serum levels of endogenesis r-hGH in patients with liver cirrhosis were higher than normal(normal level<10ng/L).The rate of patients'inappetency,abdominal distention,tired,nausea decreased more in r-hGH group than control group(P<0.05,P<0.01,P<0.01,P<0.05,respectively).When treatment stopping and 2 weeks after treatment,serum albumin increased significantly(P<0.01) in r-hGH group.Liver functions and kidney functions didn't change.Conclusion With integrating treatment,using r-hGH can decrease the symptoms of patients with liver cirrhosis rapidly,improve serum albumin and nutrition.r-hGH has no severe side effect.