血清和组织内HBV DNA定量检查的临床意义

目的探讨血液和组织内HBVDNA定量检查的临床意义。方法随机观察98例HBV急慢性感染病例血液和肝、脾、肾、脑组织内HBVDNA含量。结果急性HBV感染者血和肝组织内HBVDNA阳性率和平均含量均低于慢性感染者。治疗后血和肝组织内多数HBVDNA阴转。结论慢性HBV感染者,血和肝、脾、肾、脑组织均可查见HBVDNA;肝、脾内检出率和含量均明显高于血液。

Clinical significance of HBV DNA quantitative assay in blood and visceral tissues

Objective Anti-virus treatment method has been considered as basic measures for HBV infection,and quantitative assay of HBV DNA was needed for evaluating therapeutic effects.Method s Blood,liver,spleen,kidney and brain tissues were sampled at random from HBV infected patients for HBV DNA quantitative assay.Results The positive rate and mean concentration of HBV DNA in blood and liver tissue were comparatively low in acute hepatitis patients,but in chronic cases,both were obviously higher than that of acute cases.Most cases had negative-conversion of HBV DNA in blood and hepato-tissue after treatment .Conclusion The HBV DNA can be detected in blood,liver,spleen,kidney and brain tissues of chronic HBV infected patients and the positive rates and quantity of HBV DNA of visceral tissues were obviously higher than that of blood.So,consolidating treatment could not be neglected for the cases having had seroconversion of HBV DNA might come later owing to higher quantity for avoiding relapse.