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| Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia： case report | |
| 引用本文： | Dirican EK,Isik A,Vicdan K,Sozen E,Suludere Z. Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia： case report[J]. Asian journal of andrology, 2008, 10(2): 332-336 |
| 作者姓名： | Dirican EK Isik A Vicdan K Sozen E Suludere Z |
| 摘 要： | We report the successful outcome of intracytoplasmic sperm injection （ICSI） treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy. （Asian J Androl 2008 Mar; 10： 332-336） |
| 关 键 词： | 射精能力 精子 顶体 电子扫描术 |
Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report |
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| Dirican Enver K,Isik Ahmet,Vicdan Kubilay,Sozen Eran,Suludere Zekiye. Clinical pregnancies and livebirths achieved by intracytoplasmic injection of round headed acrosomeless spermatozoa with and without oocyte activation in familial globozoospermia: case report[J]. Asian journal of andrology, 2008, 10(2): 332-336 | |
| Authors: | Dirican Enver K Isik Ahmet Vicdan Kubilay Sozen Eran Suludere Zekiye |
| Affiliation: | Department of Embryology, Private Ankara IVF Center, Ankara 06460, Turkey |
| Abstract: | We report the successful outcome of intracytoplasmic sperm injection (ICSI) treatment in two siblings with familial globozoospermia. After controlled ovarian hyperstimulation and oocyte pick-up, retrieved oocytes were mechanically activated before ICSI and a fertilization rate of 33.3% was achieved in the first case. The second couple underwent ICSI without oocyte activation and a 9.1% fertilization rate was obtained. The transfer of two grade I embryos in the first couple and one grade I embryo in the second couple resulted in clinical pregnancies with healthy livebirths. It was concluded that the main problem of cases with globozoospermia is a low fertilization rate, and even though ICSI and oocyte activation can increase this rate it is not necessarily needed to achieve a pregnancy. |
| Keywords: | intracytoplasmic sperm injection spermatozoa acrosome scanning electron microscopy |
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