Synthesis and preliminary evaluation of difluorinated 1,3-propanediones as potential agents in the treatment of breast cancer |
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| Authors: | Tabreskhan Pathan Sachin Ingale Ashish Sharma Rhea Mohan C. S. Ramaa |
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| Affiliation: | 1. Department of Pharmaceutical Chemistry, Bharati Vidyapeeth’s College of Pharmacy, Sector-8, C. B. D. Belapur, Navi Mumbai, 400 614, Maharashtra, India
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| Abstract: | A series of difluorinated propanediones were synthesized and evaluated for in vitro cytotoxic activity by Sulforhodamine B (SRB) assay against a panel of four human cancer cell lines. Though the compounds showed varying degrees of cytotoxicity in the tested cell lines, most marked effect was observed in breast cancer cell line (MCF7), wherein nine of the ten synthesized chalcones showed good antiproliferative activity. |
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