| 单相抑郁症与5-羟色胺2A受体基因多态性的关联研究 |
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| 引用本文： | 汪广剑,仲爱芳,张理义,王焕林,赵汉清,余海鹰,邵亚琴,李宁,闫同军,胡传荣,孙芳卿,王云征.单相抑郁症与5-羟色胺2A受体基因多态性的关联研究[J].四川精神卫生,2002,15(3):147-148. |
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| 作者姓名： | 汪广剑 仲爱芳 张理义 王焕林 赵汉清 余海鹰 邵亚琴 李宁 闫同军 胡传荣 孙芳卿 王云征 |
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| 作者单位： | 213003,江苏省常州解放军第102医院 |
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| 摘 要： | 探讨中国汉族人群单相抑郁症患者与5－HT2A受体基因T102C多态性之间的关系，方法：采用AmP-RFLP方法，检测单相抑郁症患者对照组的5－HT2A受体基因频率分布。结果：单相抑郁症患者5－HT2A受体基因型频率，等位基因频率与对照组无明显差异。结论：本实验结果提示5－HT2A受体基因多态性与单相抑郁症患者未见明显相关，提示5－HT2A受体基因可能不是单相抑郁症发病的风险基因之一。
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| 关 键 词： | 单相抑郁症 5－HT2A受体基因 基因多态性 关联 |
| 修稿时间： | 2002年4月16日 |
A study on the association between gene polymorphism of serotonin 2A receptor and depression |
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| WANG Guangjian,ZHONG Eifang,ZHANG Liyi,et al..A study on the association between gene polymorphism of serotonin 2A receptor and depression[J].Sichuan Mental Health,2002,15(3):147-148. |
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| Authors: | WANG Guangjian ZHONG Eifang ZHANG Liyi |
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| Institution: | WANG Guangjian,ZHONG Eifang,ZHANG Liyi,et al.Changzhou P.L.A 102th Hospital Jiangsu.213003 |
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| Abstract: | Objective To assess the association between the gene polymorphism of the serotonin 2A receptor and depression.Methods The association between gene polymorphism of serotonin 2A receptor and depression was determind with amplification restriction fragment length polymorphism technique in healthy persons and 125 patients in Jiangsu.Results The frequency of gene type of 5-HT 2A receptor gene polymorphism and the frequency of allele in the patients group was not significant different from that than in the healthy group.Conclusion There results indicate that there is a negative association between the variation of serotonin 2A receptor gene and depression in Jiangsu China. |
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| Keywords: | Depression Serotonin 2A receptor gene Gene polymorphism Association |
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