| 重组人白细胞介素-11对环磷酰胺致犬血小板减少症的实验研究 |
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| 引用本文： | 赖伏英,方芳,孙黎,陈朝晖,何群,方云祥. 重组人白细胞介素-11对环磷酰胺致犬血小板减少症的实验研究[J]. 中国生化药物杂志, 2001, 22(6): 281-283 |
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| 作者姓名： | 赖伏英 方芳 孙黎 陈朝晖 何群 方云祥 |
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| 作者单位： | 1. 中南大学湘雅医院,湖南,长沙,410078
2. 中南大学湘雅医学院,湖南,长沙,410078 |
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| 摘 要： | 目的观察重组人白细胞介素 11(rhIL 11)对环磷酰胺致犬血小板减少症的治疗作用。方法分别用rhIL 112 0 0、10 0 μg/(kg·d)两个剂量对环磷酰胺致犬血小板减少症皮下注射 15d ,然后动态观察血小板数 ,并检测骨髓有核细胞总数和CFU Meg。结果rhIL 11能明显减轻环磷酰胺犬血小板减少的最低值 ,促进外周血小板数恢复正常 ,使骨髓有核细胞总数和CFU Meg增加 ,与对照组比较 ,有显著性差异 (P <0 .0 5 )。结论rhIL 11对环磷酰胺致犬血小板减少症有明显升高血小板的治疗作用
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| 关 键 词： | 重组人白细胞介素11 骨髓 血小板 犬 |
| 文章编号： | 1005-1678(2001)06-0281-03 |
| 修稿时间： | 2001-02-21 |
The beneficial effect of rhIL-11 on cyclophosphamide-induced low-platelet modelsof dogs |
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| LAI Fu ying ,FANG Fang ,SUN Li ,CHEN Zhao hui ,HE Qun ,FANG Yun xiang. The beneficial effect of rhIL-11 on cyclophosphamide-induced low-platelet modelsof dogs[J]. Chinese Journal of Biochemical Pharmaceutics, 2001, 22(6): 281-283 |
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| Authors: | LAI Fu ying FANG Fang SUN Li CHEN Zhao hui HE Qun FANG Yun xiang |
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| Affiliation: | LAI Fu ying 1,FANG Fang 1,SUN Li 1,CHEN Zhao hui 1,HE Qun 2,FANG Yun xiang 2 |
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| Abstract: | PurposeThe aim is to observe the effect of rhIL 11 on cyclophosphamide induced low platelet models of dogs.MethodsrhIL 11 in 2 different regimen of 200 μg/kg and 100 μg/kg were injected for 15 days respectively to cyclophosphamide induced low platelet models of dogs. The effect of the rhIL 11 on the platelet counts and the CFU meg of the marrow cell culture was observed. ResultsrhIL 11 could significantly increase the low value of platelet counts, and enhance the CFU Meg of the marrow cell cultured and the peripheral platelet counts ( P <0.05).ConclusionrhIL 11 increased platelet counts significantly on cyclophosphamide induced low platelet models of dogs. |
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| Keywords: | rhIL 11 Marrow Platelet Dog |
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