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| 实验性自身免疫性脑脊髓炎脑内咪唑啉受体密度变化初步观察 | |
| 引用本文： | 殷为勇,郑荣远,朱振国,邱伟文,潘建春,李云峰,高燕.实验性自身免疫性脑脊髓炎脑内咪唑啉受体密度变化初步观察[J].温州医学院学报,2006,36(6):510-512. |
| 作者姓名： | 殷为勇 郑荣远 朱振国 邱伟文 潘建春 李云峰 高燕 |
| 作者单位： | 1. 温州医学院第一附属医院,神经内科,浙江,温州,325000 2. 温州医学院,药学院,浙江,温州,325035 3. 北京军事医学科学院,北京,100850 |
| 基金项目： | 国家自然科学基金，浙江省自然科学基金 |
| 摘 要： | 目的:探讨咪唑啉2受体(I2R)和实验性自身免疫性脑脊髓炎(EAE)发病的关系.方法:采用放射性受体-配体饱和实验,以3H]idazoxan标记I2R,检测EAE大鼠脑内I2R受体密度和亲和力变化.结果:EAE大鼠脑组织的I2R受体密度上调74.5%(n=3,P＜0.05),I2R亲和力与对照组相比无统计学差异.结论:I2R在EAE大鼠脑组织中受体密度上调,可能与EAE发病有联系. |
| 关 键 词： | 实验性自身免疫性脑脊髓炎 咪唑啉2受体 受体-配体结合实验 |
| 文章编号： | 1000-2138(2006)06-0510-03 |
| 收稿时间： | 2006-10-11 |
| 修稿时间： | 2006年10月11 |
Primary observation on the Changes of imidazoline I2 receptors in the brain of experimental autoimmune encephalomyelitis |
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| YIN Fei-Yong, ZHENG Rong-Yuan, ZHU Zhen-Guo,et al..Primary observation on the Changes of imidazoline I2 receptors in the brain of experimental autoimmune encephalomyelitis[J].Journal of Wenzhou Medical College,2006,36(6):510-512. | |
| Authors: | YIN Fei-Yong ZHENG Rong-Yuan ZHU Zhen-Guo |
| Institution: | Department of Neurology, the First Affiliated Hospital, Wenzhou Medical College, Wenzhou 325000 |
| Abstract: | Objective:To investigate the changes of imidazoline I2 receptors in the brain of experimental autoimmune encephalomyelitis.Methods:With radioligand binding assay,the maximal binding capacity(Bmax) and dissociation constant(Kd) of imidazoline I2 receptors(labeled by 3H]idazoxan) were detected to show the changes of the density and affinity of imidazoline I2 receptors in the brain of experimental autoimmune encephalomyelitis.Results:The receptor density upregulated in EAE group than that in control(Bmax increased by 74.5%,P<0.05).No significant differences were observed in receptor's affinity between both groups.Conclusions: The upregulation of the density of imidazoline I2 receptors in the brain of EAE may be related to the pathogenesis of brain inflammation. |
| Keywords: | experimental autoimmune encephalomyelitis imidazoline I2 receptors receptor ligand binding assay |
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